This product may be stored for several days at 4 °C. The product has not been evaluated for long term freezer storage. However, other sources note that stock solutions of kynurenic acid at 100 mM, initially prepared with 5 M NaOH and subsequently diluted with saline and the pH adjusted with 2 N HCl, may be stored at -20 °C. This information has not been validated. Please see the link below to review the product datasheet:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/231/908/k3375pis.pdf
K3375
Kynurenic acid
Kynurenic acid
≥98% (HPLC), powder, NMDA receptor antagonist
Synonym(s):
4-Hydroxyquinoline-2-carboxylic acid
Sign Into View Organizational & Contract Pricing
All Photos(5)
Select a Size
Change View
250 MG
€28.50
1 G
€64.30
5 G
€221.00
About This Item
Empirical Formula (Hill Notation):
C10H7NO3
CAS Number:
Molecular Weight:
189.17
Beilstein:
147451
EC Number:
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Product Name
Kynurenic acid, ≥98%
Quality Level
Assay
≥98%
form
powder
mp
275 °C (dec.) (lit.)
SMILES string
OC(=O)c1cc(O)c2ccccc2n1
InChI
1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
InChI key
HCZHHEIFKROPDY-UHFFFAOYSA-N
Gene Information
human ... CHRNA1(1134) , CHRNA10(57053) , CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) , CHRNA5(1138) , CHRNA6(8973) , CHRNA7(1139) , CHRNA9(55584) , CHRNB1(1140) , CHRNB2(1141) , CHRNB3(1142) , CHRNB4(1143) , GRIA3(2892) , GRIA4(2893) , GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK4(2900) , GRIK5(2901) , GUCA2A(2980) , GUCA2B(2981) , NGFR(4804) , SLC23A2(9962)
rat ... Gria1(50592) , Grik1(29559) , Grin2a(24409)
Looking for similar products? Visit Product Comparison Guide
Application
Kynurenic acid has been used as a constituent in dissection saline solution for embryonic cerebral cortical cells[1] and human primary astrocytes.[2] It has also been used as a medium supplement for murine intestinal epithelial cell line, MODE-K[3] and induced pluripotent stem cell (iPSC)-derived neurons cells.[4]
Biochem/physiol Actions
Kynurenic acid (KynA) is a non-selective antagonist of N-methyl-d-aspartate (NMDA),[5] α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate receptors.[6] It blocks kainic acid neurotoxicity.[7] Kynurenic acid also blocks nicotinic acetylcholine receptors.[8] It is a by-product of tryptophan catabolic pathway.[5] Kynurenic acid is a neuromodulator and controls the levels of glutamate, dopamine, acetylcholine and α-aminobutyric acid (GABA).[9] KynA controls neuroendocrine functions and altered levels of KynA is a potential marker in depression, schizophrenia Alzheimer′s and Huntington′s diseases.[8][10] Normal levels of KynA in the brain is crucial for the cognitive function.[11]
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
related product
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Inhibiting Stearoyl-CoA Desaturase Ameliorates alpha-Synuclein Cytotoxicity
Vincent BM, et al.
Cell Reports, 25(10), 2742-2754 (2018)
Relevance of Alternative Routes of Kynurenic Acid Production in the Brain
Ramos-Chavez LA, et al.
Oxidative Medicine and Cellular Longevity, 2018 (2018)
Role of kynurenines in the neurotoxic actions of kainic acid
Behan WMH and Stone TW
British Journal of Pharmacology, 129(8), 1764-1770 (2000)
Kynurenine pathway inhibition as a therapeutic strategy for neuroprotection
Stone TW, et al.
FEBS Journal, 279(8), 1386-1397 (2012)
Kynurenic acid content in selected culinary herbs and spices
Turski MP, et al.
Journal of Chemistry, 2015, 1386-1397 (2015)
Articles
DISCOVER Bioactive Small Molecules for Neuroscience
-
Do you have any recommendations for storage after reconstitution of the product?
1 answer-
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
