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H9284

Sigma-Aldrich

Hepatitis C virus NS3 antigen 22kDa

0.5-1.4 mg/mL, ≥90% (SDS-PAGE), recombinant, expressed in E. coli

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About This Item

MDL number:
MFCD02264899
UNSPSC Code:
12352202
NACRES:
NA.32

recombinant

expressed in E. coli

Quality Level

200

Assay

≥90% (SDS-PAGE)

mol wt

22 kDa

concentration

0.5-1.4 mg/mL

shipped in

dry ice

storage temp.

−20°C

Biochem/physiol Actions

NS3 (nonstructural 3) proteinase is a non-structural protein, which is involved in the proteolytic processing of other non-structural proteins. T-cells which are specific towards the NS3 are crucial for regulating viremia.

Other Notes

HCV NS3 antigen [1450-1643]-poly-Histidine-tagged

Physical form

Solution in 8 M urea, 20 mM Tris-HCl, pH 8.0, and 200 mM imidazole.

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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R A Love et al.
Cell, 87(2), 331-342 (1996-10-18)
During replication of hepatitis C virus (HCV), the final steps of polyprotein processing are performed by a viral proteinase located in the N-terminal one-third of nonstructural protein 3. The structure of NS3 proteinase from HCV BK strain was determined by
P Martin et al.
Journal of medical virology, 74(3), 397-405 (2004-09-16)
Interferon-gamma (IFN gamma)-producing CD8+ T cells have been shown to play a key role in the control or eradication of hepatitis C virus (HCV) infections. In particular, T cells specific of the non-structural protein 3 (NS3) are often associated with
Wenjing He et al.
Oncology letters, 17(1), 1008-1018 (2019-01-19)
Ovarian cancer is the most malignant gynecologic neoplasm in women and has the worst prognosis of all cancer types in women based on the 5-year survival rates. A previous study indicated that mangiferin exerts an anti-neoplastic effect on human ovarian
Faguang Mu et al.
Oncology reports, 40(6), 3663-3673 (2018-10-03)
Although surgery and high‑dose radiotherapy have been the standard treatments for glioblastoma multiforme (GBM), these therapies are palliative, due to the high risk of local relapse. Emerging evidence has demonstrated that DNA double‑strand break (DSB) repair serves a critical role

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