Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

23120

Sigma-Aldrich

α-Chloralose

≥98.0% (chloralose, AT)

Synonym(s):

1,2-O-(2,2,2-Trichloroethylidene)-α-D-glucofuranose, Anhydro-D-glucochloral, Chloralose

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C8H11Cl3O6
CAS Number:
15879-93-3
Molecular Weight:
309.53
Beilstein:
85418
EC Number:
240-016-7
MDL number:
MFCD00005542
UNSPSC Code:
12352201
PubChem Substance ID:
57648022
NACRES:
NA.21
Pricing and availability is not currently available.

Assay

≥98.0% (chloralose, AT)

form

powder

optical activity

[α]20/D +17±2°, 5 hr, c = 2% in ethanol

impurities

15% Beta-chloralose

mp

178-184 °C

solubility

water: soluble 1 gm in 225 ml at 15 °C
chloroform: slightly soluble
diethyl ether: soluble
glacial acetic acid: soluble
petroleum ether: insoluble

SMILES string

OC[C@@H](O)[C@H]1O[C@@H]2O[C@@H](O[C@@H]2[C@H]1O)C(Cl)(Cl)Cl

InChI

1S/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7-/m1/s1

InChI key

OJYGBLRPYBAHRT-IPQSZEQASA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

Biochem/physiol Actions

α-Chloralose stimulates the gama-aminobutyric acid (GABA)-induced chloride conductance of gama-aminobutyric acidA (GABAA) receptors expressed in Xenopus laevis oocytes.[1]

Components

mixture of isomers of ~85% α-chloralose; ~15% β-chloralose

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Statements

H301,H332,H336,H410

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCK0932
BCCH8687
BCCF1953
BCCC7714
BCCC5785

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

K M Garrett et al.
The Journal of pharmacology and experimental therapeutics, 285(2), 680-686 (1998-05-15)
alpha-Chloralose is widely used as an anesthetic in the laboratory due to its minimal effects on autonomic and cardiovascular systems, yet little is known about its mechanism of action. We examined the effects of alpha-chloralose on gamma-aminobutyric acid type A
R W Gear et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 19(16), 7175-7181 (1999-08-06)
We tested the hypothesis that noxious stimuli induce pain modulation by activation of supraspinal structures. We found that intense noxious stimuli (i.e., subdermal injection of capsaicin or paw immersion in hot water) induced profound attenuation of the jaw-opening reflex in
Congwu Du et al.
The European journal of neuroscience, 30(8), 1565-1575 (2009-10-14)
Most studies of the effect of cocaine on brain activity in laboratory animals are preformed under anesthesia, which could potentially affect the physiological responses to cocaine. Here we assessed the effects of two commonly used anesthetics [alpha-chloralose (alpha-CHLOR) and isofluorane
Karla Krautwald et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 32(2), 291-305 (2011-08-25)
To study how various anesthetics affect the relationship between stimulus frequency and generated functional magnetic resonance imaging (fMRI) signals in the rat dentate gyrus, the perforant pathway was electrically stimulated with repetitive low frequency (i.e., 0.625, 1.25, 2.5, 5, and
Kazuto Masamoto et al.
Advances in experimental medicine and biology, 662, 57-61 (2010-03-06)
The present study aimed to characterize microcirculatory responses to anesthesia in brain tissue. With multi-photon excitation fluorescence microscopy, intra-cortical capillary dimension and red blood cell (RBC) flow were successfully visualized up to a depth of approximately 0.6 mm from the
View All Related Papers

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service