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Key Documents

P1890000

Piperacillin

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

Piperacillin monohydrate

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About This Item

Empirical Formula (Hill Notation):
C23H27N5O7S · H2O
CAS Number:
66258-76-2
Molecular Weight:
535.57
UNSPSC Code:
41116107
NACRES:
NA.24
Pricing and availability is not currently available.

grade

pharmaceutical primary standard

API family

piperacillin

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

−20°C

SMILES string

S1[C@H]2N([C@H](C1(C)C)C(=O)O)C(=O)[C@H]2NC(=O)[C@H](NC(=O)N4CCN(C(=O)C4=O)CC)c3ccccc3.O

InChI

1S/C23H27N5O7S.H2O/c1-4-26-10-11-27(19(32)18(26)31)22(35)25-13(12-8-6-5-7-9-12)16(29)24-14-17(30)28-15(21(33)34)23(2,3)36-20(14)28;/h5-9,13-15,20H,4,10-11H2,1-3H3,(H,24,29)(H,25,35)(H,33,34);1H2/t13-,14-,15+,20-;/m1./s1

InChI key

NBXPLBPWMYNZTC-IDYPWDAWSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Piperacillin EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317,H412

Hazard Classifications

Aquatic Chronic 3 - Skin Sens. 1B

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

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Brian D VanScoy et al.
Antimicrobial agents and chemotherapy, 58(10), 6024-6031 (2014-07-30)
It is important to understand the relationship between antibiotic exposure and the selection of drug resistance in the context of therapy exposure. We sought to identify the ceftolozane-tazobactam exposure necessary to prevent the amplification of drug-resistant bacterial subpopulations in a
Sangil Jeon et al.
Antimicrobial agents and chemotherapy, 58(7), 3744-3751 (2014-04-23)
Piperacillin in combination with tazobactam, a β-lactamase inhibitor, is a commonly used intravenous antibiotic for the empirical treatment of infection in intensive care patients, including burn patients. The purpose of this study was to develop a population pharmacokinetic (PK) model
Ashley W Sturm et al.
Pharmacotherapy, 34(1), 28-35 (2013-07-19)
To evaluate the steady-state pharmacokinetic and pharmacodynamic parameters of piperacillin in morbidly obese, surgical intensive care patients. Open-label single-center prospective study. Level I trauma center and university-affiliated teaching institution. Nine morbidly obese (body mass index [BMI] 40.0 kg/m² or higher)
Raquel Cavalcanti Dantas et al.
Journal of medical microbiology, 63(Pt 12), 1679-1687 (2014-09-28)
The rates of multidrug-resistant, extensively drug-resistant and pandrug-resistant isolates amongst non-fermenting Gram-negative bacilli, particularly Pseudomonas aeruginosa, have risen worldwide. The clinical consequence of resistance and the impact of adverse treatment on the outcome of patients with P. aeruginosa bacteraemia remain
Imen Mokdad-Bzeouich et al.
The Journal of antibiotics, 68(3), 148-152 (2014-09-25)
In this particular study, the antibacterial activity of esculin and oligomer fractions was assessed. MIC values of esculin and its oligomer fractions as well as of some antibiotics against Gram-positive and Gram-negative strains and against Escherichia coli multiresistant variants were
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Questions

  1. I can not find any information about the reconstitution. How much and what has to be added to the powder?

    1 answer

    1. Product reference P1890000 Piperacillin is an European Pharmacopoeia (EP) Reference Standard as indicated in the product web page. The use of primary reference standards is prescribed by the issuing pharmacopeia.
      EP Materials are supplied exclusively as European Pharmacopoeia Chemical Reference Substances, Biological Reference Preparations or Reference Spectra (Ph. Eur. CRS, BRP or RS) for use as reference standards in tests and assays carried out in accordance with the official methods of the European Pharmacopoeia (Ph. Eur.) and for no other purpose.

      Here is how to access the information for part number P1890000:
      1) Access the EDQM website by clicking on the blue link "EDQM reference substance catalog" in the "Description" section of the product web page.
      https://crs.edqm.eu/
      2) Select "Catalog code" and enter the reference of the desired standard (P1890000)
      3) Click on the reference in blue

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