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G1506

Sigma-Aldrich

Guanylyl(3′→5′)cytidine ammonium salt

Synonym(s):

GpC

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About This Item

Linear Formula:
C19H25N8O12P · NH3
CAS Number:
98046-67-4
Molecular Weight:
605.45
MDL number:
MFCD00058649
UNSPSC Code:
41106305
PubChem Substance ID:
24895064

form

solid

storage temp.

−20°C

SMILES string

N.NC1=NC(=O)c2ncn(C3OC(CO)C(OP(O)(=O)OCC4OC(C(O)C4O)N5C=CC(N)=NC5=O)C3O)c2N1

InChI

1S/C19H25N8O12P.H3N/c20-8-1-2-26(19(33)23-8)16-11(30)10(29)7(38-16)4-36-40(34,35)39-13-6(3-28)37-17(12(13)31)27-5-22-9-14(27)24-18(21)25-15(9)32;/h1-2,5-7,10-13,16-17,28-31H,3-4H2,(H,34,35)(H2,20,23,33)(H3,21,24,25,32);1H3

InChI key

PPSONIOCBRREER-UHFFFAOYSA-N

Application

Guanylyl(3′5′)cytidine is an oligonucleotide pyrimidine dimer used as a substrate to study the specificity and kinetics of various RNases such as RNase T1 and its mutations.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Lot/Batch Number
012H7832

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Martin Vincent et al.
Genome biology, 18(1), 38-38 (2017-02-23)
The study of epigenetic heterogeneity at the level of individual cells and in whole populations is the key to understanding cellular differentiation, organismal development, and the evolution of cancer. We develop a statistical method, epiG, to infer and differentiate between
Marc Struhalla et al.
Chembiochem : a European journal of chemical biology, 5(2), 200-205 (2004-02-05)
Although ribonuclease T1 (RNase T1) is one of the best-characterized proteins with respect to structure and enzymatic action, numerous attempts at altering the specificity of the enzyme to cleave single-stranded RNA at the 3'-side of adenylic instead of guanylic residues
Rico Czaja et al.
Biochemistry, 43(10), 2854-2862 (2004-03-10)
Attempts to alter the guanine specificity of ribonuclease T1 (RNase T1) by rational or random mutagenesis have failed so far. The RNase T1 variant RV (Lys41Glu, Tyr42Phe, Asn43Arg, Tyr45Trp, and Glu46Asn) designed by combination of a random and a rational
Yang Wang et al.
Nature communications, 12(1), 1247-1247 (2021-02-25)
Extensive epigenetic reprogramming occurs during preimplantation embryo development. However, it remains largely unclear how the drastic epigenetic reprogramming contributes to transcriptional regulatory network during this period. Here, we develop a single-cell multiomics sequencing technology (scNOMeRe-seq) that enables profiling of genome-wide
Francisco Requena et al.
Scientific reports, 9(1), 8140-8140 (2019-06-01)
Recent technical advances highlight that to understand mammalian development and human disease we need to consider transcriptional and epigenetic cell-to-cell differences within cell populations. This is particularly important in key areas of biomedicine like stem cell differentiation and intratumor heterogeneity.
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