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1225281

USP

Dorzolamide hydrochloride

United States Pharmacopeia (USP) Reference Standard

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About This Item

Fórmula empírica (notación de Hill):
C10H16N2O4S3 · HCl
Número de CAS:
130693-82-2
Peso molecular:
360.90
Beilstein:
5896026
Número MDL:
MFCD00884659
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329749667
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

dorzolamide

fabricante / nombre comercial

USP

aplicaciones

pharmaceutical (small molecule)

formato

neat

cadena SMILES

Cl.CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(N)(=O)=O

InChI

1S/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16;/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16);1H/t6-,8-;/m0./s1

Clave InChI

OSRUSFPMRGDLAG-QMGYSKNISA-N

Información sobre el gen

human ... CA2(760)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Dorzolamide hydrochloride USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Dorzolamide Hydrochloride and Timolol Maleate Ophthalmic Solution
  • Dorzolamide Hydrochloride Ophthalmic Solution

Nota de análisis

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Otras notas

Sales restrictions may apply.

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Referencia del producto
Descripción
Precios

Y0000726

Dorzolamide hydrochloride, European Pharmacopoeia (EP) Reference Standard

Y0000750

Dorzolamide for system suitability, European Pharmacopoeia (EP) Reference Standard

Y0000727

Dorzolamide Impurity A, European Pharmacopoeia (EP) Reference Standard

1225292

Dorzolamide hydrochloride Related Compound A, United States Pharmacopeia (USP) Reference Standard

1225306

Dorzolamide Related Compound D, United States Pharmacopeia (USP) Reference Standard

BP1069

Dorzolamide hydrochloride, British Pharmacopoeia (BP) Reference Standard

BP1071

Dorzolamide impurity D, British Pharmacopoeia (BP) Reference Standard

BP1070

Dorzolamide impurity B, British Pharmacopoeia (BP) Reference Standard

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palabra de señalización

Warning

Frases de peligro

H302,H373

Clasificaciones de peligro

Acute Tox. 4 Oral - STOT RE 2

Órganos de actuación

Central nervous system,Gastrointestinal tract,Bone,Blood,Bladder

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Timolol maleate European Pharmacopoeia (EP) Reference Standard

T1450000

Timolol maleate

M F Sugrue
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 12(3), 363-376 (1996-01-01)
Dorzolamide hydrochloride (S,S-5,6-dihydro-4H-4-ethylamino-6-methylthieno [2,3-b]thiopyran-2-sulfonamide-7,7-dioxide HCl; MK-507; L-671,152) is a water-soluble, potent inhibitor of human carbonic anhydrase isoenzymes II and IV in vitro, the respective IC50 values being 0.18 nM and 6.9 nM. In contrast, it was found to be a
Göktuğ Seymenoğlu et al.
Journal of glaucoma, 24(2), 111-116 (2013-06-29)
To compare the efficacy of fixed combinations of dorzolamide-timolol (FCDT) and brimonidine-timolol (FCBT) in patients with intraocular pressure (IOP) elevations after intravitreal triamcinolone acetonide (IVTA) injections. This was a prospective, randomized, open-label study. Patients who received IVTA injections due to
Azza A Hasan
Pharmaceutical development and technology, 19(6), 748-754 (2013-08-24)
The objective of this work was to formulate and characterize non-ionic surfactant vesicles (niosomes) as an ocular carrier of dorzolamide hydrochloride (Dorzo); one of the antiglaucoma drugs. Niosomes were prepared of Cholesterol (Chol) with sorbitan monoesters (Span 20, 40, 60)
Masamichi Fukuda et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 31(1), 57-60 (2014-10-11)
We investigated the transcorneal penetration of commercial ophthalmic formulations containing timolol maleate in rabbit eyes. One drop (30 μL) of each ophthalmic solution (Xalacom(®), DuoTrav(®), Cosopt(®), and Timoptol(®)) was administered to the conjunctival sac of the rabbits' eyes and the

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