The SPME-LC fiber probes are intended as single-use devices for the extraction of small molecules out of a fluid followed by solvent desorption and LC analysis.
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Metabolomics and biomarkers discovery are an integral part of bioanalysis. However, untargeted tissue analysis remains as the bottleneck of such studies due to the invasiveness of sample collection, as well as the laborious and time-consuming sample preparation protocols. In the
Journal of pharmaceutical and biomedical analysis, 47(4-5), 907-912 (2008-05-13)
Pharmacokinetic (PK) studies in rats typically involve removal of serial blood samples following dosing. This research illustrates the development of a fast in vivo microextraction technique that has the potential to partly replace current sampling techniques based on blood draws
In Vivo Sampling of Environmental Organic Contaminants in Fish by Solid-Phase Microextraction
Zhang, X., et al.
TrAC, Trends in Analytical Chemistry, 32, 31-39 (2012)
Solid-Phase Microextraction. How Far are We from Clinical Practice?
Bojko, B., et al.
TrAC, Trends in Analytical Chemistry, 30 (9), 1505-1512 (2011)
Metabolic Profiling of Plasma from Cardiac Surgical Patients Concurrently Administered with Tranexamic Acid: DI-SPME?LC?MS Analysis
Bojko, B., et al.
Journal of Pharmaceutical Analysis, 4 (1), 6-13 (2014)
Accurate protein binding affinities were measured using bioSPME more rapidly than membrane dialysis (RED) techniques. Binding affinities correlated to the reference values.
A demonstration of the use of innovative BioSPME fibers for the selective extraction of drugs and polar metbolites from biological matrices.
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