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Merck

47864

Supelco

Nicotinic acid

analytical standard

Sinónimos:

3-Picolinic acid, Niacin, Pellagra preventive factor, Pyridine-3-carboxylic acid, Vitamin B3

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About This Item

Fórmula empírica (notación de Hill):
C6H5NO2
Número de CAS:
Peso molecular:
123.11
Beilstein:
109591
Número CE:
Número MDL:
Código UNSPSC:
12164500
ID de la sustancia en PubChem:

grado

analytical standard

CofA

current certificate can be downloaded

Características

standard type water soluble vitamin

envase

ampule of 1000 mg

técnicas

HPLC: suitable
gas chromatography (GC): suitable

mp

236-239 °C (lit.)

densidad

1.473 g/cm3 at 25 °C

aplicaciones

pharmaceutical (small molecule)
vitamins, nutraceuticals, and natural products

formato

neat

temp. de almacenamiento

2-30°C

cadena SMILES

OC(=O)c1cccnc1

InChI

1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)

Clave InChI

PVNIIMVLHYAWGP-UHFFFAOYSA-N

Información sobre el gen

human ... CYP1A2(1544)
rat ... Chrnb2(54239)

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Descripción general

Nicotinic acid acts as an antilipolytic drug in adipose tissue, and is commonly used for hyperlipoproteinaemia and pellagra.
Nicotinic acid is a water soluble, vitamin belonging to B complex group of vitamins, which can be used as a broad spectrum lipid lowering drug. Its mode of action basically involves the inhibition of the hormone-sensitive triglyceride lipase and thereby, decreasing the lipolysis in adipose tissue.

Aplicación

Nicotinic acid may be used as an analytical reference standard for the quantification of the analyte in tablet dosage forms using reversed-phase high-performance liquid chromatography technique.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictogramas

Exclamation mark

Palabra de señalización

Warning

Frases de peligro

Clasificaciones de peligro

Eye Irrit. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

379.4 °F - closed cup

Punto de inflamabilidad (°C)

193 °C - closed cup

Equipo de protección personal

dust mask type N95 (US), Eyeshields, Gloves


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Certificados de análisis (COA)

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Los clientes también vieron

Nicotinic acid: the broad?spectrum lipid drug. A 50th anniversary review
Carlson.A.L
J. Int. Med., 258, 94-114 (2005)
Molecular identification of nicotinic acid receptor
Soga T, et al.
Biochemical and Biophysical Research Communications, 303, 364-369 (2003)
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
Tunaru S, et al.
Nature Medicine, 9, 352-352 (2003)
RP-HPLC method for the determination of atorvastatin calcium and nicotinic acid in combined tablet dosage form
Shah DA, et al.
Indian Journal of Pharmaceutical Sciences, 69(5), 700-700 (2007)
Sorin Tunaru et al.
Nature medicine, 9(3), 352-355 (2003-02-04)
Nicotinic acid (niacin), a vitamin of the B complex, has been used for almost 50 years as a lipid-lowering drug. The pharmacological effect of nicotinic acid requires doses that are much higher than those provided by a normal diet. Its

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