WH0001634M1

Monoclonal Anti-DCN antibody produced in mouse

clone 3H4-1F4, purified immunoglobulin, buffered aqueous solution

• Sinónimos: Anti-DSPG2, Anti-PG40, Anti-PGII, Anti-PGS2, Anti-SLRR1B, Anti-decorin
• Número MDL: MFCD00282305
• Código UNSPSC: 12352203
• NACRES: NA.41

Propiedades

• origen biológico: mouse
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: purified immunoglobulin
• tipo de anticuerpo: primary antibodies
• clon: 3H4-1F4, monoclonal
• Formulario: buffered aqueous solution
• reactividad de especies: human
• técnicas: immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; indirect ELISA: suitable; western blot: 1-5 μg/mL
• isotipo: IgG2bκ
• Nº de acceso GenBank: BC005322
• Nº de acceso UniProt: P07585
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... DCN(1634)

Descripción

Descripción general

Decorin (DCN) protein is encoded by the gene mapped to human chromosome 12q21.33. DCN is an extracellular matrix protein with leucine-rich repeats. The protein belongs to the small leucine-rich proteoglycan (SLRP) gene family.

Inmunógeno

DCN (AAH05322, 1 a.a. ~ 359 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Sequence
MKATIILLLLAQVSWAGPFQQRGLFDFMLEDEASGIGPEVPDDRDFEPSLGPVCPFRCQCHLRVVQCSDLGLDKVPKDLPPDTTLLDLQNNKITEIKDGDFKNLKNLHALILVNNKISKVSPGAFTPLVKLERLYLSKNQLKELPEKMPKTLQELRAHENEITKVRKVTFNGLNQMIVIELGTNPLKSSGIENGAFQGMKKLSYIRIADTNITSIPQGLPPSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLHNNNISVVGSSDFCPPGHNTKKASYSGVSLFSNPVQYWEIQPSTFRCVYVRSAIQLGNYK

Acciones bioquímicas o fisiológicas

Decorin (DCN) acts as a structural and signaling molecule and is involved in extracellular matrix assembly. It is implicated in the regulation of fibrogenesis and inflammation. DCN exhibits antimetastatic and antiangiogenic activities by inducing cell cycle arrest and apoptosis. It is used as a marker to detect the prognosis of various types of cancers such as breast, bladder, and lung cancer. Mutation in the DCN gene is associated with the development of posterior amorphous corneal dystrophy (PACD).

Forma física

Solution in phosphate buffered saline, pH 7.4

Información legal

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Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)