V6629

Vitamina B₁₂

BioReagent, suitable for cell culture, suitable for insect cell culture, suitable for plant cell culture, ≥98%

• Sinónimos: α-(5,6-Dimetilbencimidazolil)cianocobamida, CN-Cbl, Cianocob(III)alamina, Cianocobalamina
• Fórmula empírica (notación de Hill): C₆₃H₈₈CoN₁₄O₁₄P
• Número de CAS: 68-19-9
• Peso molecular: 1355.37
• Beilstein: 4122889
• Número CE: 200-680-0
• Código UNSPSC: 12352205
• eCl@ss: 34058004
• ID de la sustancia en PubChem: 24900763
• NACRES: NA.75

Propiedades

• origen biológico: synthetic ((organic))
• Nivel de calidad: 200
• Línea del producto: BioReagent
• Ensayo: ≥98%
• Formulario: powder
• mol peso: M_w 1355.37 g/mol
• técnicas: cell culture | insect: suitable; cell culture | mammalian: suitable; cell culture | plant: suitable
• color: red to brown
• pH: 6
• solubilidad: water: soluble 50 mg/mL, dark red
• temp. de almacenamiento: 2-8°C
• cadena SMILES: C/C(C1=N[C@]([C@]([C@H](CC(N)=O)[C@@]/2(C)CCC(NC[C@@H](OP([O-])(O[C@H]3[C@@H](O)[C@@H](N4C=[N]5C6=C4C=C(C)C(C)=C6)O[C@@H]3CO)=O)C)=O)([H])N([Co+]5C#N)C2=C(C)/C([C@@H](CCC(N)=O)C/7(C)C)=NC7=C/8)(C)[C@@](C)(CC(N)=O)[C@@H]1CCC(N)=O)=C9N=C8[C@@H](CCC(N)=O)[C@
• InChI: 1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+2/p-2/t31-,34-,35-,36-,37+,41-,52-,53-,56-,57?,59-,60+,61+,62+;;/m1../s1
• Clave InChI: RMRCNWBMXRMIRW-QJRSUKKJSA-L

Descripción

Descripción general

Cyanocobalamin (B12) is a water soluble vitamin, commonly called as cobalamins. Dairy products, meat and eggs are the major sources of this vitamin.

Aplicación

Vitamin B12 has been used:

• as a component of Erdschreiber′s medium
• as a supplement of Dulbecco′s modified Eagle′s medium used for the isolation of ventricular myocytes from neonatal and adult rats
• orally administered to male quails to study its role in reducing the negative effects of sodium selenite intoxication, in vivo
• as a supplement in DMEM/ medium 199 (M199) medium for differentiation of human myoblasts.

Acciones bioquímicas o fisiológicas

Vitamin B12 is metabolized to its active form, methylcobalamin. Hindered vitamin B12 uptake is observed in pernicious anemia. Vitamin B12 is essential for erythroblast development. Pregnancy reduces the levels of vitamin B12. Aging reduces vitamin B12 absorption. It works as a coenzyme in fat, carbohydrate and protein metabolism. It is required for growth, genetic stability and survival of cells in vitro. Functions to support one-carbon metabolism. Present in many classical and serum-free formulations.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)