V5765
VEGF165
recombinant, expressed in HEK 293 cells, suitable for cell culture
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.77
Productos recomendados
origen biológico
human
Nivel de calidad
recombinante
expressed in HEK 293 cells
descripción
Vascular Endothelial Growth Factor 165 human
Análisis
≥95% (SDS-PAGE)
formulario
lyophilized powder
potencia
<10 ng/mL ED50
calidad
endotoxin tested
mol peso
dimer 42 kDa (glycosylated)
envase
pkg of 10 μg
pkg of 50 μg
técnicas
cell culture | mammalian: suitable
impurezas
<0.075 EU/μg
color
white
solubilidad
water: soluble
Nº de acceso UniProt
temp. de almacenamiento
−20°C
Información sobre el gen
human ... VEGFA(7422)
Descripción general
VEGF165 is expressed in human HEK 293 cells as a glycosylated homodimer with an apparent molecular mass of 45 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.
Acciones bioquímicas o fisiológicas
VEGF165 belongs to the PDGF/VEGF growth factor family characterized by the presence of eight conserved cysteine residues and a cystine knot structure. VEGF is secreted by the majority of tumor cells and initiates angiogenesis by activating endothelial cells of existing blood vessels and promoting their migration.
VEGF has also been implicated in correlation with poor prognosis in breast cancer.
In addition, VEGF is released in rheumatoid arthritis in response to TNF-α, increasing endothelial permeability and stimulating angiogenesis (formation of capillaries).
VEGF has also been implicated in correlation with poor prognosis in breast cancer.
In addition, VEGF is released in rheumatoid arthritis in response to TNF-α, increasing endothelial permeability and stimulating angiogenesis (formation of capillaries).
Nota de análisis
The specific activity was determined by the dose-dependent stimulation of the proliferation of HUVEC cells (human umbilical vein endothelial cells).
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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The expansion of the synovial lining of joints in rheumatoid arthritis (RA), and the subsequent invasion by the pannus of underlying cartilage and bone, necessitates an increase in the vascular supply to the synovium, to cope with the increased requirement
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