U8881

UCL 1684 ditrifluoroacetate hydrate

• Sinónimos: 6,12,19,20,25,26-hexahydro- 5,27:13,18:21,24-Trietheno-11,7-metheno-7H-dibenzo[b,m][1,5,12,16]tetraazacyclotricosine-5,13-diium ditrifluoroacetate hydrate
• Fórmula lineal: (C₃₄H₃₀N₄)²⁺ · (C₂F₃O₂^-)₂ · xH₂O
• Número de CAS: 201147-19-5
• Peso molecular: 720.66 (anhydrous basis)
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24900684
• NACRES: NA.77

Propiedades

• color: white to off-white
• solubilidad: DMSO: 10 mg/mL
• cadena SMILES: [H]O[H].FC(F)(C(O)=O)F.FC(F)(C(O)=O)F.C12=CC=CC=C1C(NCC3=CC=C(CNC4=CC=[N+](C5)C6=C4C=CC=C6)C=C3)=CC=[N+]2CC7=CC=CC5=C7
• InChI: 1S/C34H28N4.2C3H3F3O2.H2O/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31;2*4-3(5,6)1-2(7)8;/h1-20H,21-24H2;2*1H2,(H,7,8);1H2/b35-31+,36-32+;;;
• Clave InChI: YROHEYZVNZITJN-DDVHGCDCSA-N

Descripción

Aplicación

UCL 1684 ditrifluoroacetate hydrate has been used for analyzing the mechanism for ammonium-mediated displacement of the protonated analyte from analyte-trifluoroacetic acid (TFA) ion-pair[1]. UCL 1684 has also been used as a potassium channel inhibitor to study CNP (C-type natriuretic peptide)-induced relaxations in pig coronary arteries[2].

Acciones bioquímicas o fisiológicas

UCL 1684 is a potent non-peptide blocker of the apamin-sensitive Ca²⁺-activated K⁺ channel.[3] It comprises two quinolinium rings and is similar to apamin arginine residue.[4] UCL 1684 inhibits calcium-activated K current (Kslow) and modulates islet β-cell.[5]

Características y beneficios

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparación

UCL 1684 ditrifluoroacetate hydrate is soluble in water at 10 mg/ml.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)