This product may be reconstituted in 0.01M phosphate buffer at pH 7.5. Stock solutions, prepared at 10 micro IU per milliliter, may be stored frozen in aliquots. Avoid repeated freeze/thaw cycles. Working solutions should be prepared fresh and not stored.
T9265
Thyrotropic hormone from human pituitary
lyophilized powder, ≥6.2 IU/mg (immunoassay, non-sterile)
Sinónimos:
hTSH, TSH, Thyroid stimulating hormone
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5 μG
150,00 €
10 μG
264,00 €
25 μG
524,00 €
0.1 MG
1740,00 €
150,00 €
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5 μG
150,00 €
10 μG
264,00 €
25 μG
524,00 €
0.1 MG
1740,00 €
About This Item
150,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Solicitar un pedido a granel
Productos recomendados
origen biológico
human pituitary glands
Nivel de calidad
esterilidad
non-sterile
Formulario
lyophilized powder
actividad específica
≥6.2 IU/mg (immunoassay, non-sterile)
condiciones de almacenamiento
(Keep container tightly closed in a dry and well-ventilated place)
técnicas
cell culture | mammalian: suitable
impurezas
HIV Antibodies
Antibody to HCV
Antibody to HBV or Presence of HBSAG, tested negative
Condiciones de envío
ambient
temp. de almacenamiento
2-8°C
Información sobre el gen
human ... TSHB(7252) , TSHR(7253)
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Descripción general
Research area: Cell Signaling
Thyrotropic hormone or thyroid stimulating hormone (TSH) belongs to the glycoprotein hormone family.[1] Thyrotroph cells of the anterior pituitary gland produces TSH and is stored in the secretory granules. It comprises a heterodimer of two noncovalently linked subunits, α and β.[2]
Thyrotropic hormone or thyroid stimulating hormone (TSH) belongs to the glycoprotein hormone family.[1] Thyrotroph cells of the anterior pituitary gland produces TSH and is stored in the secretory granules. It comprises a heterodimer of two noncovalently linked subunits, α and β.[2]
Aplicación
Thyrotropic hormone from human pituitary has been used as a supplement in the fetal thyroid organoid culture medium for stimulating maturation.[3] It has also been used as a medium supplement for primary cell culture, and is used further to study the molecular mechanisms of estrogen-mediated growth stimulation of human thyroid tumor cells.[4]
Acciones bioquímicas o fisiológicas
In children, thyroid hormones are very much essential for the normal cognition and neurodevelopment.[5] Thyroid-stimulating hormone (TSH) test is mainly used to diagnose thyroid function.[6]
The product can enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer celllines.[7]TSHR activated by TSH activates both the adenosine 3′,5′-cyclic monophosphate (cAMP) pathway (via Gsa) and the phosphoinositol/calcium (IP/Ca2+; via Gq) second messenger signaling pathway by interacting with Gs and Gq G-proteins.[8] In mature adipocytes, TSH aids in lipid metabolism by inhibiting fatty acid synthase (FASN) expression via, activating protein kinase A (PKA)-dependent phosphorylation of extracellular signal-regulated kinases/p42/p44 (ERK1/2), and c-Jun N-terminal kinase (JNK).[9]
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.
Envase
Package size based on hormone
Forma física
Contains hormone and salts from approx. 0.1 mL of 0.05 M phosphate buffer, pH 7.4.
Producto relacionado
anticuerpo
Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Thyroid-stimulating hormone
The pituitary, 163-201 (2017)
D Manole et al.
The Journal of clinical endocrinology and metabolism, 86(3), 1072-1077 (2001-03-10)
Thyroid tumors are about 3 times more frequent in females than in males. Epidemiological studies suggest that the use of estrogens may contribute to the pathogenesis of thyroid tumors. In a very recent study a direct growth stimulatory effect of
Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships
Szkudlinski MW, et al.
Physiological Reviews, 82(2), 473-502 (2002)
Zhenghao Wu et al.
Journal for immunotherapy of cancer, 10(1) (2022-02-02)
Hormones are identified as key biological variables in tumor immunity. However, previous researches mainly focused on the immune effect of steroid hormones, while the roles that thyroid-stimulating hormone (TSH) played in the antitumor response were far from clear. The source
Physiology, Thyroid Stimulating Hormone
Pirahanchi Y, et al.
StatPearls [Internet] (2022)
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