T8944
Topoisomerase II α human
(Single band on SDS-PAGE), liquid
Sinónimos:
Topoisomerase II alpha, TOPO® II, p170
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About This Item
Número MDL:
Código UNSPSC:
12352204
NACRES:
NA.54
Productos recomendados
Nivel de calidad
formulario
liquid
mol peso
170 kDa
Nº de acceso UniProt
temp. de almacenamiento
−70°C
Información sobre el gen
human ... TOP2A(7153)
Descripción general
Topoisomerase II α (TopoIIα) is a gene product with conserved catalytic activities and it promotes the progression of DNA damage. The α isoform is present in proliferating cells.
Topoisomerase II α is encoded by TOP2A gene, which is located on 17q21.2 in the human chromosome. It is essential for controlling the topological state of DNA by reversibly breaking the DNA strands during replication, recombination and transcription. TOP2A expression increases at late S phase and during G2/M of the cell cycle and decreases after mitosis. Polymorphism with TOP2A causes chromosome instability and tumorigenesis. TOP2A causes tumor proliferation and invasiveness in various cancer types like breast cancer, ovarian cancer and prostate cancer.
Aplicación
Human topoisomerase II α has been used in DNA cleavage assay.
Topoisomerase II α has been used in a study to assess aging processes in the human brain. Topoisomerase II α has also been used in a study to investigate its activity in HIV-1 replication.
Acciones bioquímicas o fisiológicas
Used to study DNA structure and topology.
Definición de unidad
One unit will decatenate 0.2 μg of kinetoplast DNA in 30 minutes at 37°C.
Forma física
Buffered aqueous glycerol solution, containing Trizma buffer (pH 7.7). Other components are present in the solution, and lot-specific information on these components may be obtained from Technical Service.
Nota de preparación
Recombinant enzyme overexpressed in a proprietary eukaryotic cell line.
Información legal
TOPO is a registered trademark of Life Technologies
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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TOP2A induces malignant character of pancreatic cancer through activating beta-catenin signaling pathway.
Pei YF, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1864(1), 197-207 (2018)
J R Spitzner et al.
Nucleic acids research, 16(12), 5533-5556 (1988-06-24)
Topoisomerase II, purified from chicken erythrocytes, was reacted with a large number of different DNA fragments and cleavages were catalogued in the presence and absence of drugs that stabilize the cleavage intermediate. Cleavages were sequenced to derive a consensus for
M Vanni et al.
Poultry science, 93(4), 856-863 (2014-04-08)
Escherichia coli are a common inhabitant of the gastrointestinal tract of mammals and birds; nevertheless, they may be associated with a variety of severe and invasive infections. Whereas fluoroquinolones (FQ) have been banned in the United States for use in
Maryjean Pendleton et al.
Annals of the New York Academy of Sciences, 1310, 98-110 (2014-02-06)
Type II topoisomerases are essential enzymes that modulate DNA under- and overwinding, knotting, and tangling. Beyond their critical physiological functions, these enzymes are the targets for some of the most widely prescribed anticancer drugs (topoisomerase II poisons) in clinical use.
Topoisomerase 2 alpha: a real predictor of anthracycline efficacy?
Romero A, et al.
Clinical And Translational Oncology, 14(3), 163-168 (2012)
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