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T8024

Sigma-Aldrich

Tetrodotoxin

≥98% (HPLC), powder

Sinónimos:

Fugu poison, Maculotoxin, TTX, Tarichatoxin

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About This Item

Fórmula empírica (notación de Hill):
C11H17N3O8
Número de CAS:
4368-28-9
Peso molecular:
319.27
Beilstein:
49176
Número CE:
224-458-8
Número MDL:
MFCD00213719
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24900493

Análisis

≥98% (HPLC)

formulario

powder

color

white

solubilidad

dilute citrate or acetate buffer: 1 mg/mL (dissolve at pH 4-5. Aqueous solutions, pH 4-5, are stable if stored frozen.)
strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)

temp. de almacenamiento

2-8°C

cadena SMILES

[H][C@]12OC3(O)OC(C4[C@@H](O)NC(=N)NC4([C@@H]1O)[C@@H]3O)[C@@]2(O)CO

InChI

1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2?,3-,4?,5+,6-,7+,9+,10?,11?/m1/s1

Clave InChI

CFMYXEVWODSLAX-IXUBDLNJSA-N

Información sobre el gen

rat ... Scnn1g(24768)

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Aplicación

Tetrodotoxin has been used as standard during HPLC-based analysis of biotoxins from P. punctata tentacles whole crude extract (PHY-N). Tetrodotoxin has also been used to study its effects on low-threshold transient (LTT) Ca2+ currents in rat hippocampal interneurons.

Acciones bioquímicas o fisiológicas

Reversible, selective blocker of Na+ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.

Nota de preparación

Tetrodotoxin is soluble in dilute citrate or acetate buffer at 1 mg/ml (pH 4-5). Aqueous solutions are stable at pH 4-5 if stored frozen. However, tetrodotoxin is unstable in strong acid or alkaline solutions and is destroyed by boiling at pH2.

Pictogramas

Skull and crossbones
GHS06

Palabra de señalización

Danger

Frases de peligro

H300

Consejos de prudencia

P301 + P330 + P331 + P310

Clasificaciones de peligro

Acute Tox. 1 Oral

Código de clase de almacenamiento

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Clase de riesgo para el agua (WGK)

WGK 3

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Sigma-Aldrich

N9407

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