T5651

Tetrodotoxin with Citrate Buffer

pH 4.8, powder

• Sinónimos: Fugu poison, Maculotoxin, TTX, Tarichatoxin
• Fórmula empírica (notación de Hill): C₁₁H₁₇N₃O₈
• Número de CAS: 4368-28-9
• Peso molecular: 319.27
• Beilstein: 49176
• Número MDL: MFCD00213719
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24900308

Propiedades

• formulario: powder
• disponibilidad: not available in USA
• pH: 4.8
• solubilidad: H₂O: soluble (stable at pH 4-5 if stored frozen); strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)
• temp. de almacenamiento: 2-8°C
• cadena SMILES: OC[C@@]1(O)[C@H]2OC3(O)OC1C4[C@@H](O)NC(=N)NC4([C@@H]2O)[C@@H]3O
• InChI: 1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2?,3-,4?,5+,6-,7+,9+,10?,11?/m1/s1
• Clave InChI: CFMYXEVWODSLAX-IXUBDLNJSA-N
• Información sobre el gen: rat ... Scnn1g(24768)

Descripción

Aplicación

Tetrodotoxin has been used to study its effects on microglial functions in rats². This toxin has also been used to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in juvenile zebra finch. This study reported that the toxin causes a decrease in sequence and acoustic variability which result in the production of a stereotyped song by the motor pathway³.

Acciones bioquímicas o fisiológicas

Reversible, selective blocker of Na⁺ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.

Envase

Vial contains 1 mg of tetrodotoxin and approx. 5 mg citrate buffer, pH 4.8.

Nota de preparación

The product is water soluble and stable at pH 4-5 if it is stored frozen. It is unstable in strong acid and alkaline solutions and is rapidly destroyed by boiling at pH 2 and below.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300
• Consejos de prudencia: P301 + P330 + P331 + P310
• Clasificaciones de peligro: Acute Tox. 1 Oral
• Código de clase de almacenamiento: 6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable