T5443

Tyrphostin AG 825

≥92.5%

• Sinónimos: 5-[(Benzothiazol-2-yl)thiomethyl]-4-hydroxy-3-methoxybenzylidenecyanoacetamide, Tyrphostin C15
• Fórmula empírica (notación de Hill): C₁₉H₁₅N₃O₃S₂
• Número CAS: 149092-50-2
• Peso molecular: 397.47
• NACRES: NA.77
• PubChem Substance ID: 329826823
• UNSPSC Code: 12352200
• MDL number: MFCD01074971
• Assay: ≥92.5%
• Form: powder

Propiedades

• Quality Segment: 200
• assay: ≥92.5%
• form: powder
• solubility: DMSO: soluble, methanol: soluble
• storage temp.: −20°C
• SMILES string: COc1cc(cc(CSc2nc3ccccc3s2)c1O)\C=C(/C#N)C(N)=O
• InChI: 1S/C19H15N3O3S2/c1-25-15-8-11(6-12(9-20)18(21)24)7-13(17(15)23)10-26-19-22-14-4-2-3-5-16(14)27-19/h2-8,23H,10H2,1H3,(H2,21,24)/b12-6+
• InChI key: KXDONFLNGBQLTN-WUXMJOGZSA-N

Descripción

Application

Tyrphostin AG 825 has been used to study its effects on iodide uptake in EMT6 cells¹.

Biochem/physiol Actions

EGF receptor tyrosine kinase inhibitor, inactive against IGF-1 Receptor.

Tyrphostin AG 825 has been used in combination with hypericin-mediated photodynamic therapy (HY-PDT) for evaluating its therapeutic effects in HER2 overexpressing human breast cancer cells. This study reported that AG 825 combination increased the induction of cell death, HER2 degradation and inhibited colony formation in cancer cells².

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Preparation Note

Tyrphostin AG 825 is soluble in DMSO and methanol.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): Eyeshields, Gloves, type N95 (US)