T4512

(±)-Taxifolin hydrate

≥90% (HPLC)

• Sinónimos: 3,3′,4′,5,7-Pentahydroxyflavanone hydrate, Dihydroquercetin hydrate
• Fórmula empírica (notación de Hill): C₁₅H₁₂O₇ · xH₂O
• Número CAS: 24198-97-8
• Peso molecular: 304.25 (anhydrous basis)
• NACRES: NA.25
• PubChem Substance ID: 24278739
• UNSPSC Code: 12352200
• MDL number: MFCD11044454

Propiedades

• Quality Segment: 100
• assay: ≥90% (HPLC)
• form: powder
• solubility: DMSO: 20 mg/mL
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• storage temp.: −20°C
• SMILES string: O.O[C@@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c3ccc(O)c(O)c3
• InChI: 1S/C15H12O7.H2O/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6;/h1-5,14-19,21H;1H2/t14-,15+;/m0./s1
• InChI key: DNQPGSVMBPSRIR-LDXVYITESA-N
• Gene Information: mouse ... Hexa(15211)

Descripción

General description

Taxifolin or dihydroquercetin is a naturally occurring secondary metabolic compound found in many plants such as onions, milk thistle, Douglas fir bark, and French maritime pine bark.

Application

(±)-Taxifolin hydrate has been used to evaluate its effects when co-supplemented with trehalose to improve the quality of post-thawed ram semen. It may have been used as a reference standard to analyze the bioactive components of ethanolic extract of P. orientale (POE) using high-performance liquid chromatography (HPLC).

Biochem/physiol Actions

(±)-Taxifolin exerts various pharmacological properties that include anti-inflammatory, anti-cancer, antiviral, and antimicrobial activities. It displays neuroprotective, hepatoprotective effects, and it also protects against cardiovascular diseases.

Flavonoid, antioxidant. Inhibits lipogenesis in cancer cells, most likely by targeting fatty acid synthase activity.

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H302
• Indicaciones de precaución: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): dust mask type N95 (US), Eyeshields, Gloves