T0167

D-(+)- Trealosa dihydrate

from Saccharomyces cerevisiae, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99%

• Sinónimos: α,α-Trealosa, α-D-Glucopiranosil-α-D-glucopiranósido
• Fórmula empírica (notación de Hill): C₁₂H₂₂O₁₁ · 2H₂O
• Número de CAS: 6138-23-4
• Peso molecular: 378.33
• Beilstein: 5322018
• Número CE: 202-739-6
• Número MDL: MFCD00071594
• Código UNSPSC: 12352201
• ID de la sustancia en PubChem: 24899871
• NACRES: NA.75

Propiedades

• Nivel de calidad: 200
• origen biológico: Saccharomyces cerevisiae
• Línea del producto: BioReagent
• Ensayo: ≥99%
• Formulario: powder
• técnicas: cell culture | insect: suitable; cell culture | mammalian: suitable
• solubilidad: H₂O: 50 mg/mL
• cadena SMILES: [H]O[H].[H]O[H].OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1
• Clave InChI: DPVHGFAJLZWDOC-PVXXTIHASA-N

Descripción

Descripción general

Trehalose is a non-reducing disaccharide, ubiquitously present in nature. It is used as a food preservative and also to retain enzymes, vaccines, cells and many other molecules.[1] Trehalose is present as hemolymph sugar among the invertebrates.[2]

Aplicación

D-(+)-Trehalose dihydrate has been used in a slow-freezing method for freezing rabbit oocytes.[2] It has also been used in solid-surface vitrification (SSV) of in vitro-matured oocytes.[3][4] It is suitable for use as a cryoprotectant in a variety of cell freezing media.

Acciones bioquímicas o fisiológicas

Trehalose is essential for embryogenesis, carbon metabolism, photosynthesis and flowering in plants. It predominantly exists among the species that supports anhydrobiosis (life without water).[1] It serves as a carbohydrate reserve in microorganisms and protects them from adverse conditions,[5] such as heat, cold, dehydration, desiccation and oxidation.[2] Trehalose acts as a chemical chaperone affecting protein folding. It is known to prevent amyloid generation and accummulation of β-amyloid in vitro. A similar effect of trehalose has been observed with huntingtin protein aggregation. Thus, it might serve as a protective agent in Alzheimer′s disease and Huntington′s disease.[2]

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)