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Key Documents

SRP3210

Sigma-Aldrich

IL-33 from mouse

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.32

origen biológico

mouse

recombinante

expressed in E. coli

Análisis

≥98% (HPLC)
≥98% (SDS-PAGE)

formulario

lyophilized

potencia

≤10 ng/mL ED50

mol peso

17.5 kDa

envase

pkg of 10 μg

técnicas

cell culture | mammalian: suitable

impurezas

<0.1 EU/μg endotoxin, tested

color

white to off-white

Nº de acceso UniProt

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Información sobre el gen

mouse ... IL33(77125)

Descripción general

IL-33 (interleukin 33) is an IL-1 family member, and shows high expression levels in endothelial cells and epithelium, such as keratinocytes, that are in direct contact with the environment.
Recombinant murine IL-33 is a 17.5kDa protein containing 158 amino acid residues.

Acciones bioquímicas o fisiológicas

IL-33 (interleukin 33) functions as an extracellular cytokine, and also translocates to the nucleus where it inhibits gene expression. It acts as a ligand for ST2/ IL-1 receptor-like 1 (growth STimulation expressed gene 2), and ST2 is expressed on cells such as CD34+ hematopoietic progenitor cells, eosinophils, basophils, T-helper 2 cell (Th2), and dendritic, NK (natural killer), endothelial and mast cells. Polymorphisms in this gene as well as its receptor are linked with atopic dermatitis, allergies and asthma. In Orientia tsutsugamushi-infected mice, IL-33 is involved in endothelial cell damage and renal injury.
Recombinant murine IL-33 is a 17.5kDa protein containing 158 amino acid residues.

Secuencia

SIQGTSLLTQ SPASLSTYND QSVSFVLENG CYVINVDDSG KDQEQDQVLL RYYESPCPAS QSGDGVDGKK LMVNMSPIKD TDIWLHANDK DYSVELQRGD VSPPEQAFFV LHKKSSDFVS FECKNLPGTY IGVKDNQLAL VEEKDESCNN IMFKLSKI

Forma física

Lyophilized from 10 mM Sodium Phosphate, pH 8.0 + 750mM NaCl.

Reconstitución

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Atsushi Kurokawa et al.
Respiratory research, 22(1), 166-166 (2021-06-03)
Obesity-associated asthma is a phenotype of severe asthma. Late-onset, non-eosinophilic and female-dominant phenotype is highly symptomatic and difficult to treat. Leptin, an adipokine, exerts an immunomodulatory effect. IL-33 associated with innate immunity induces type 2 inflammation and is present in
IL-33-Dependent Endothelial Activation Contributes to Apoptosis and Renal Injury in Orientia tsutsugamushi-Infected Mice.
Shelite TR et al
PLoS Neglected Tropical Diseases, 10(3), e0004467-e0004467 (2016)
Targeting the IL-1 family members in skin inflammation.
Jensen LE
Current Opinion in Investigational Drugs, 11(11), 1211-1220 (2010)
Elizabeth A Oczypok et al.
The Journal of allergy and clinical immunology, 136(3), 747-756 (2015-05-02)
Single nucleotide polymorphisms in the human gene for the receptor for advanced glycation end-products (RAGE) are associated with an increased incidence of asthma. RAGE is highly expressed in the lung and has been reported to play a vital role in
Ying Lei et al.
PloS one, 10(7), e0133774-e0133774 (2015-07-28)
In several clinical and experimental studies IL-33 and its receptor have been found to play important roles in the development of asthma and allergic airway inflammation. We evaluated the effects of vaccination against IL-33 in a mouse model of airway

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