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Key Documents

SRP2036

Sigma-Aldrich

BRG1, wild type human

recombinant, expressed in insect cells, ≥80% (SDS-PAGE)

Sinónimos:

BAF190, BRG1, FLJ39786, RTPS2, SNF2, SNF2-beta, SNF2L4, SNF2LB, SWI2, hSNF2b

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About This Item

Código UNSPSC:
12352200
NACRES:
NA.26

origen biológico

human

recombinante

expressed in insect cells

Análisis

≥80% (SDS-PAGE)

formulario

frozen liquid

mol peso

~185 kDa

envase

pkg of 5 μg

condiciones de almacenamiento

avoid repeated freeze/thaw cycles

concentración

300 μg/mL

color

clear
 colorless

Nº de acceso NCBI

NM_003072

Nº de acceso UniProt

P51532

Condiciones de envío

dry ice

temp. de almacenamiento

−70°C

Información sobre el gen

human ... SMARCA4(6597)

Acciones bioquímicas o fisiológicas

The wild type human brahma-related gene 1 (Brg1) encodes a protein of 1,647 amino acids that contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription regulation. BRG1 is an essential component of the SWI/SNF chromatin remodeling complexes and implicated in multiple functions through its interaction with different proteins, including the tumor suppressor protein pRb, serine-threonine kinase LKB1, and other transcription factors. Although Brg1 is involved in chromatin remodeling as a complex with other SWI/SNF proteins, purified BRG1 itself is capable of remodeling mono-nucleosomes and nucleosomal arrays in vitro. Mutations of Brg1 have been found in multiple tumor cell lines.

Forma física

Clear and colorless frozen liquid solution

Nota de preparación

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

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S Sif et al.
Genes & development, 12(18), 2842-2851 (1998-09-23)
During mitosis, chromatin is condensed into mitotic chromosomes and transcription is inhibited, processes that might be opposed by the chromatin remodeling activity of the SWI/SNF complexes. Brg1 and hBrm, which are components of human SWI/SNF (hSWI/SNF) complexes, were recently shown
C J Fryer et al.
Nature, 393(6680), 88-91 (1998-05-20)
The assembly of transcriptional regulatory DNA sequences into chromatin plays a fundamental role in modulating gene expression. The promoter of the mouse mammary-tumour virus (MMTV) is packaged into a regular array of nucleosomes when it becomes stably integrated into mammalian
P A Khavari et al.
Nature, 366(6451), 170-174 (1993-11-11)
Sequence-specific DNA binding activators of gene transcription may be assisted by SWI2 (SNF2), which contains a DNA-dependent ATPase domain. We have isolated a human complementary DNA encoding a 205K nuclear protein, BRG1, that contains extensive homology to SWI2 and Drosophila

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