SRP0324
MECP2 human
recombinant, expressed in E. coli, ≥70% (SDS-PAGE)
Sinónimos:
MRX16, PPMX, RTS, methyl CpG binding protein 2 (Rett syndrome)
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.32
Productos recomendados
origen biológico
human
recombinante
expressed in E. coli
Ensayo
≥70% (SDS-PAGE)
Formulario
aqueous solution
mol peso
36 kDa
envase
pkg of 50 μg
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
human ... MECP2(4204)
Descripción general
Human recombinant Methyl CpG binding Protein 2 (Rett syndrome) (MECP2), (GenBank Accession No. NM_004992), amino acids 78-162 with N-terminal GST-tag, MW= 36 kDa, expressed in an E. coli expression system.
Methyl-CpG binding protein 2 (MECP2) is encoded by the gene mapped to human chromosome Xq28. Higher molecular weight form of hMeCP2 is expressed in frontal cortex nuclear and synaptic fractions, and in lymphoid cells. Fibroblast and lymphoblastoid strains of female patients with Rett syndrome and MeCP2 transfected cells also show expression of high molecular weight form of MeCP2.2The encoded chromosomal protein is characterized with the 80 amino acid-containing methyl-CpG binding domain, involved in chromosomal localization of the protein.
Aplicación
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Acciones bioquímicas o fisiológicas
Methyl-CpG binding protein 2 (MECP2) plays a vital role in regulation of a wide range of genes in the hypothalamus, and aids in both activation and repression of transcription. Mutation of the gene leads to a severe neurodevelopmental disorder associated with hypotonia, spasticity, severe learning disability, delayed psychomotor development, and recurrent pulmonary infections in males. Impairment in the expression of MeCP2 protein results in various neurological disorders such as Rett syndrome and Autism.
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin.
Nan X
Cell, 88, 471-481 (1997)
Rett Syndrome Mutant Neural Cells Lacks MeCP2 Immunoreactive Bands.
Bueno C
PLoS ONE, 11 (2016)
R E Amir et al.
Nature genetics, 23(2), 185-188 (1999-10-03)
Rett syndrome (RTT, MIM 312750) is a progressive neurodevelopmental disorder and one of the most common causes of mental retardation in females, with an incidence of 1 in 10,000-15,000 (ref. 2). Patients with classic RTT appear to develop normally until
J D Lewis et al.
Cell, 69(6), 905-914 (1992-06-12)
Methylation of mammalian DNA can lead to repression of transcription and alteration of chromatin structure. Recent evidence suggests that both effects are the result of an interaction between the methylated sites and methyl-CpG-binding proteins (MeCPs). MeCP1 has previously been detected
Yu-Chiao Huang et al.
Plant molecular biology, 90(1-2), 127-135 (2015-11-02)
Sucrose synthase (SuS), which catalyzes the reversible conversion of sucrose and uridine diphosphate (UDP) into fructose and UDP-glucose, is a key enzyme in sucrose metabolism in higher plants. SuS belongs to family 4 of the glycosyltransferases (GT4) and contains an
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