SML3219

Tenofovir alafenamide

≥98% (HPLC), HIV and HBV reverse transcriptase inhibitor, powder

• Sinónimos: 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]-methoxy]-propyl]adenine, GS 7340, GS-7340, GS7340, TAF
• Fórmula empírica (notación de Hill): C₂₁H₂₉N₆O₅P
• Número CAS: 379270-37-8
• Peso molecular: 476.47
• NACRES: NA.77
• UNSPSC Code: 51111800
• MDL number: MFCD28976050
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: Tenofovir alafenamide, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: CC(OC([C@@H](N[P@](CO[C@@H](CN1C2=NC=NC(N)=C2N=C1)C)(OC3=CC=CC=C3)=O)C)=O)C
• InChI: 1S/C21H29N6O5P/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24)/t15-,16+,33+/m1/s1
• InChI key: LDEKQSIMHVQZJK-CAQYMETFSA-N

Descripción

Biochem/physiol Actions

HIV and HBV reverse transcriptase inhibitor tenofovir isopropylalaninyl phenyl ester with greater antiviral efficacy than tenofovir disoproxil fumarate.

Tenofovir alafenamide (TAF; GS-7340) is an isopropylalaninyl phenyl ester prodrug of the nucleotide analog reverse transcriptase inhibitor (nRTI) tenofovir (TFV) against human immunodeficiency virus (HIV) and hepatitis B virus (HBV). GS-7340 more efficiently delivers TFV into lymphoid cells and tissues than tenofovir disoproxil fumarate (TDF), resulting in greater antiviral efficacy against HIV.

Información de seguridad

• Pictogramas: GHS05
• Palabra de advertencia: Danger
• Códigos de peligro: H318
• Indicaciones de precaución: P280 - P305 + P351 + P338
• Hazard Classifications: Eye Dam. 1
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable