SML3011

MG149

≥98% (HPLC)

• Sinónimos: 2-(4-Heptylphenethyl)-6-hydroxybenzoic acid, 2-[2-(4-Heptylphenyl)ethyl]-6-hydroxybenzoic acid, MG 149
• Fórmula empírica (notación de Hill): C₂₂H₂₈O₃
• Número CAS: 1243583-85-8
• Peso molecular: 340.46
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD22123243
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: OC1=C(C(CCC2=CC=C(C=C2)CCCCCCC)=CC=C1)C(O)=O
• InChI: 1S/C22H28O3/c1-2-3-4-5-6-8-17-11-13-18(14-12-17)15-16-19-9-7-10-20(23)21(19)22(24)25/h7,9-14,23H,2-6,8,15-16H2,1H3,(H,24,25)
• InChI key: WBHQYBZRTAEHRR-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

MG149 is cell-permeable anacardic acid analog that displays higher selectivity towards MYST type HATs (IC50 = 47 and 74 μM against MOF and Tip60; Ki for KAT8 = 39 μM) over p300 and PCAF (IC50 > 200 and >> 200 uM). Tip60 inhibition is shown to be Ac-CoA competitive and histone substrate non-competitive and KAT8 inhibition is Ac-CoA uncompetitive. MG149 treatment lowers histone acetylation levels and cellular proliferation rate, induces apoptosis and dose-dependently alters pro-inflammatory cytokines/chemokines expression. Enhances JQ1-induced HIV latency reversal, suppresses NOX transcription and ameliorates ROS levels.

cell-permeable anacardic acid analog that displays higher selectivity towards MYST type HATs over p300 and PCAF

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable