SML2940

ML417

≥98% (HPLC)

• Sinónimos: (1H-Indol-2-yl)(4-(2-(4-methoxyphenoxy)ethyl)piperazin-1-yl)methanone, Methanone, 1H-indol-2-yl[4-[2-(4-methoxyphenoxy)ethyl]-1-piperazinyl]-
• Fórmula empírica (notación de Hill): C₂₂H₂₅N₃O₃
• Número CAS: 1386162-69-1
• Peso molecular: 379.45
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD32693923
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: N2(CCN(CC2)C(=O)c3[nH]c4c(c3)cccc4)CCOc1ccc(cc1)OC
• InChI key: HAZPAMUWUHDPDA-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

ML417 is a blood-brain barrier permeable, potent and highly selective agonist of D3 dopamine receptor (D3R) with very limited cross-reactivity at other GPCRs. ML417 potently induces G-protein activation, D3R-mediated b-arrestin translocation and pERK phosphorylation. It does not activate other dopamine receptors. ML417 protect D3R-expressing dopaminergic neurons from 6-OHDA induced cell death.

blood-brain barrier permeable, potent and highly selective agonist of D3 dopamine receptor (D3R)

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable