SML2812

AN1

≥98% (HPLC)

• Sinónimos: 5-Bromo-3-[(3-bromo-4,5-dihydroxyphenyl)methylene]-1,3-dihydro-2H-indol-2-one, mHTT-LC3 linker AN1
• Fórmula empírica (notación de Hill): C₁₅H₉Br₂NO₃
• Número CAS: 486443-73-6
• Peso molecular: 411.04
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: Brc1c(c(cc(c1)C=C2c3c(ccc(c3)Br)NC2=O)O)O
• InChI: 1S/C15H9Br2NO3/c16-8-1-2-12-9(6-8)10(15(21)18-12)3-7-4-11(17)14(20)13(19)5-7/h1-6,19-20H,(H,18,21)
• InChI key: GPKLWRHHVIBYEO-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

AN1 is a brain blood barrier penetrant agent that tether LC3 and mHTT and targets mHTT for autophagosome degradation. AN1 significantly lower mHTT in cortices of HD mice, in cells from patients with Huntington′s disease, and neurons derived from induced pluripotent stem cells. AN1 does not lower wtHTT in fibroblasts from healthy human donors. It appears that AN1 interact with the polyQ stretch.

brain blood barrier penetrant agent that tether LC3 and mHTT and targets mHTT for autophagosome degradation

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable