They wouldn't tell me what the thing is dissolved in, preventing me from having the proper vehicle control for experimentation. Disappointing service.
SML2709
Sphingosine 1-phosphate
≥95% (TLC), liquid, Lipid second messenger
Sinónimos:
(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate, D-erythro-Sphingosine 1-phosphate, S1P
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| A ustedes/SKU | Disponibilidad | Precio |
|---|---|---|
0.1 mL | Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad | 112,00 € |
Acerca de este artículo
Fórmula empírica (notación de Hill):
C18H38NO5P
Peso molecular:
379.47
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (TLC)
Form:
liquid
112,00 €
Póngase en contacto con nuestro Servicio de Atención al Cliente para disponibilidad
Servicio técnico
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Permítanos ayudarleNombre del producto
Sphingosine 1-phosphate ready made solution, ≥95% (TLC), Fully soluble 10mM solution
Quality Segment
assay
≥95% (TLC)
form
liquid
storage temp.
−20°C
General description
Sphingosine 1-phosphate (S1P) is a sphingolipid derived from ceramide by an enzymatic reaction in vivo.1 S1P acts as a signaling molecule by binding to G-protein coupled receptors (S1PR) (S1P1-5 receptors) which results in activation of small GTPases such as Ras, Rac Rho and further downstream intracellular effects such as PI-3-Kinase, Protein kinase C and Hippo signaling pathways. This generates an effect on cell migration, differentiation and survival and therefore effects variety of systems such as immune system, central nervous system and cardiovascular system.2 For instance, S1P was found to inhibit cell apoptosis and induce cell proliferation by binding S1P1 to promote activation of ERK pathway.3 In addition, S1P was found to support cancer cells by inducing angiogenesis and survival of proliferative cells in the tumor microenvironment.4 Due to the vast activities of S1P and the resulted S1PR irregular activation, large discovery efforts are made to identify therapy by S1PR antagonists.5
Biochem/physiol Actions
Anti angigoenesis
Other Notes
Sphingosine 1-phosphate ready made solution is supplied in aqueous solution at 10mM concentration and can be further diluted (X10000) to a working concentration of 1μM.
1 of 1
Este artículo | |||
|---|---|---|---|
| description ≥95% (TLC), Fully soluble 10mM solution | description ≥95%, powder | description ≥98.0% (TLC) | description A putative second messenger that mobilizes calcium from intracellular stores via an IP3-independent pathway. |
| assay ≥95% (TLC) | assay ≥95% | assay ≥98.0% (TLC) | assay ≥95% (elemental analysis) |
| form liquid | form powder | form powder | form solid |
| Quality Level 100 | Quality Level 300 | Quality Level 100 | Quality Level 100 |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Clase de almacenamiento
12 - Non Combustible Liquids
wgk
WGK 2
Listados normativos
Los listados normativos se proporcionan para los productos químicos principalmente. Para los productos no químicos sólo se puede proporcionar información limitada. Si no hay ninguna entrada, significa que ninguno de los componentes está en la lista. Es obligación del usuario garantizar el uso seguro y legal del producto.
109-89-7
CAS No.
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