SML2675

CuET

≥97% (HPLC)

• Sinónimos: Copper bis(N,N-diethyldithiocarbamate), Cupric diethyldithiocarbamate, Merkupral, NSC 177697, bis(N,N-Diethyldithiocarbamato)copper(II)
• Fórmula empírica (notación de Hill): C₁₀H₂₀CuN₂S₄
• Número CAS: 13681-87-3
• Peso molecular: 360.09
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00070506
• Assay: ≥97% (HPLC)
• Form: powder
• Storage condition: desiccated

Propiedades

• assay: ≥97% (HPLC)
• form: powder
• storage condition: desiccated
• color: dark green to black
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CCN(CC)C(S[Cu]SC(N(CC)CC)=S)=S
• InChI: 1S/2C5H11NS2.Cu/c2*1-3-6(4-2)5(7)8;/h2*3-4H2,1-2H3,(H,7,8);/q;;+2/p-2
• InChI key: OBBCYCYCTJQCCK-UHFFFAOYSA-L

Descripción

Biochem/physiol Actions

CuET, a metabolite of disulfiram, is an inhibitor of p97 segregase adaptor NPL4 that exhibits potent anti-cancer effects. Apparently CuET binds NPL4 and induces its aggregation, which disables the vital p97–NPL4–UFD1 pathway and induces to cell death.

Inhibitor of NPL4

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable