KA-11 is a broad-spectrum anticonvulsant hybrid molecule that joins the chemical fragments of well-known anti-epileptic drugs such as ethosuximide, levetiracetam, and lacosamide. KA-11 was shown to have antiepileptogenic and antinociceptive properties in animal models. Its mechanism of action is believed to involve influence on the neuronal voltage-sensitive sodium and L-type calcium channels.
Journal of medicinal chemistry, 58(13), 5274-5286 (2015-06-09)
The library of 27 new 1-(4-phenylpiperazin-1-yl)- or 1-(morpholin-4-yl)-(2,5-dioxopyrrolidin-1-yl)propanamides and (2,5-dioxopyrrolidin-1-yl)butanamides as potential new hybrid anticonvulsant agents was synthesized. These hybrid molecules join the chemical fragments of well-known antiepileptic drugs (AEDs) such as ethosuximide, levetiracetam, and lacosamide. Compounds 5, 10, 11
ACS chemical neuroscience, 10(1), 636-648 (2018-09-25)
Recently, compound KA-11 was identified as a promising candidate for a new broad-spectrum anticonvulsant. This compound revealed wide protective activity across the most important animal models of seizures such as the maximal electroshock test (MES), the subcutaneous pentylenetetrazole test (
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