SML2487

Cabazitaxel

≥95% (HPLC), taxane microtubule inhibitor, powder

• Sinónimos: 1-hydroxy-7β,10β-dimethoxy-9-oxo-5β,20-epoxytax-11-ene-2α,4,13α-triyl 4-acetate 2-benzoate 13-[(2R,3S)-3-[[(tert-butoxy)carbonyl]amino]-2-hydroxy-3-phenylpropanoate], DEP cabazitaxel, Jevtana, TXD 258, XRP 6258, XRP-6258, dimethoxydocetaxel
• Fórmula empírica (notación de Hill): C₄₅H₅₇NO₁₄
• Número CAS: 183133-96-2
• Peso molecular: 835.93
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD18827611
• Assay: ≥95% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: Cabazitaxel, ≥95% (HPLC)
• assay: ≥95% (HPLC)
• form: powder
• optical activity: [α]/D -36 to -44°, c = 0.5 in methanol
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: −20°C
• SMILES string: N([C@H]([C@@H](O)C(=O)O[C@H]2C[C@]3([C@H]([C@@H]5[C@]6([C@H](OC6)C[C@@H]([C@]5(C(=O)[C@@H](C(=C2C)C3(C)C)OC)C)OC)OC(=O)C)OC(=O)c4ccccc4)O)c1ccccc1)C(=O)OC(C)(C)C
• InChI: 1S/C45H57NO14/c1-24-28(57-39(51)33(48)32(26-17-13-11-14-18-26)46-40(52)60-41(3,4)5)22-45(53)37(58-38(50)27-19-15-12-16-20-27)35-43(8,36(49)34(55-10)31(24)42(45,6)7)29(54-9)21-30-44(35,23-56-30)59-25(2)47/h11-20,28-30,32-35,37,48,53H,21-23H2,1-10H3,(H,46,52)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1
• InChI key: BMQGVNUXMIRLCK-OAGWZNDDSA-N

Descripción

Biochem/physiol Actions

Cabazitaxel is a synthetic taxane microtubule inhibitor and anticancer agent. It acts by stabilization of microtubules, promoting tubulin assembly into microtubules but inhibiting disassembly, resulting in the inhibition of mitotic and interphase cellular functions.

Synthetic taxane microtubule inhibitor

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H302,H315,H341,H361fd,H373
• Indicaciones de precaución: P202 - P260 - P264 - P301 + P312 - P302 + P352 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Muta. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 2
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 2
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable