SML2304

Clozapine N-oxide hydrochloride

≥98% (HPLC), powder, muscarinic DREADD activator

• Sinónimos: Clozapine N-oxide hydrochloride, 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide, hydrochloride salt
• Fórmula empírica (notación de Hill): C₁₈H₁₉ClN₄O · xHCl
• Número CAS: 34233-69-7
• Peso molecular: 342.82 (free base basis)
• UNSPSC Code: 12352119
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Propiedades

• Nombre del producto: Clozapine N-oxide hydrochloride, ≥98% (HPLC), Water soluble Clozapine N-oxide
• biological source: synthetic
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• solubility: DMSO: 40 mg/mL, water: 40 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: ClC1=CC2=C(NC(C=CC=C3)=C3C(N4CC[N+]([O-])(C)CC4)=N2)C=C1.[xHCl]
• InChI: 1S/C18H19ClN4O/c1-23(24)10-8-22(9-11-23)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
• InChI key: OGUCZBIQSYYWEF-UHFFFAOYSA-N

Descripción

General description

Clozapine N-oxide hydrochloride is a water soluble form of Clozapine N-oxide (CNO) (Sigma cat# C0832). CNO is a pharmacologically inert metabolite of the atypical anti-psychotic drug clozapine. CNO is a ligand for the engineered Gq protein coupled receptors (GPCRs) in the chemogenetic Designer Receptors Exclusively Activated by Designer Drug (DREADD). The typical use of DREADD is testing, enhancing neuronal firing and activating Gq signaling in neuronal and non-neuronal cells.

The selective targeting of DREADD systems to cell population can be achieved by using a cell type-specific promoter to drive DREADD expression, and the expression of this promoter can be further controlled using a recombinase-based system. DREADDs possess a low affinity for endogenous ligands and little constitutive activity, but may be activated by synthetic compounds such as CNO.

DREADD systems are activated by low nM concentrations of CNO and mobilize intracellular calcium. CNO appears to be pharmacologically and behaviorally inert in mice and rats when administered at the recommended doses (generally 0.1–3 mg/kg). CNO is commonly administrated via injection but also can be mixed into food chow or drinking water.

Other Notes

This is not a pharmaceutical grade product.

Información de seguridad

• Pictogramas: GHS06
• Palabra de advertencia: Danger
• Códigos de peligro: H301,H336
• Indicaciones de precaución: P261 - P264 - P271 - P301 + P310 - P304 + P340 + P312 - P403 + P233
• Hazard Classifications: Acute Tox. 3 Oral - STOT SE 3
• Órganos diana: Central nervous system
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable