SML2064

LBQ657

≥97% (HPLC), neprilysin inhibitor, powder

• Sinónimos: (2R,4S)-5-(Biphenyl-4-yl)-4-((3-carboxypropionyl)amino)-2-methylpentanoic acid, Desethyl sacubitril, Sacubitrilat
• Fórmula empírica (notación de Hill): C₂₂H₂₅NO₅
• Número CAS: 149709-44-4
• Peso molecular: 383.44
• NACRES: NA.77
• UNSPSC Code: 12352200
• MDL number: MFCD00921225
• Assay: ≥97% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: LBQ657, ≥97% (HPLC)
• assay: ≥97% (HPLC)
• form: powder
• optical activity: [α]/D -35 to -27°, c = 1 in methanol
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: OC(CCC(N[C@H](CC1=CC=C(C2=CC=CC=C2)C=C1)C[C@H](C(O)=O)C)=O)=O
• InChI: 1S/C22H25NO5/c1-15(22(27)28)13-19(23-20(24)11-12-21(25)26)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h2-10,15,19H,11-14H2,1H3,(H,23,24)(H,25,26)(H,27,28)/t15-,19+/m1/s1
• InChI key: DOBNVUFHFMVMDB-BEFAXECRSA-N

Descripción

Biochem/physiol Actions

Inhibitor of neprilysin (neutral endopeptidase, NEP) formed by the action of esterases on its prodrug sacubitril (AHU377)

LBQ657 is the active metabolite of sacubitril. It is an inhibitor of the enkephalinase neprilysin (neutral endopeptidase, NEP) formed by the action of esterases on its prodrug sacubitril (AHU377), which is half of the heart failure combination drug Entresto, along with the angiotensin-receptor blocker Valsartan. LBQ657 prevents neprilysin′s degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides.

Información de seguridad

• Pictogramas: GHS08,GHS07
• Palabra de advertencia: Danger
• Códigos de peligro: H336,H372
• Indicaciones de precaución: P260 - P264 - P271 - P304 + P340 + P312 - P314 - P403 + P233
• Hazard Classifications: STOT RE 1 - STOT SE 3
• Órganos diana: Bone,Kidney, Central nervous system
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable