SML2022
UCSF924
≥98% (HPLC)
Sinónimos:
6-Methyl-2-((3-phenoxypropylamino)methyl)quinolin-4(1H)-one, ZINC000091726127
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About This Item
Fórmula empírica (notación de Hill):
C20H22N2O2
Número de CAS:
Peso molecular:
322.40
Código UNSPSC:
12352200
NACRES:
NA.77
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Análisis
≥98% (HPLC)
formulario
powder
color
white to beige
solubilidad
DMSO: 2 mg/mL, clear
temp. de almacenamiento
−20°C
cadena SMILES
CC1=CC=C(NC(CNCCCOC2=CC=CC=C2)=CC3=O)C3=C1
Acciones bioquímicas o fisiológicas
UCSF924 (Compound 9-6-24; ZINC000091726127) is a selective, high-affinity dopamine D4 receptor (DRD4) partial agonist (Ki = 3 nM for human D4) with a 7.4-fold bias toward arrestin recruitment over Gαi (Gαi/0; Gi/G0) signaling activation with respect to quinpirole. UCSF924 exhibits no detectable affinity for D2, D3 or the F261V/L328F D4 mutant and no agonist activity toward a panel of 320 nonolfactory GPCRs even at a high concentration of 1 μM. The UCSF924 structure analog UCSF924NC (Comound 9-6-16; ZINC000091707446) is the recommended negative control compound with a 1/2500-fold reduced D4 affinity.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
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