SML1692

AS8351

≥98% (HPLC)

• Sinónimos: 2-Hydroxy-1-naphthylaldehyde isonicotinoylhydrazone, 311 Iron Chelator, AS-8351, NSC-51355
• Fórmula empírica (notación de Hill): C₁₇H₁₃N₃O₂
• Número CAS: 796-42-9
• Peso molecular: 291.30
• NACRES: NA.77
• PubChem Substance ID: 329826020
• UNSPSC Code: 12352200
• MDL number: MFCD00033110
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: −20°C
• SMILES string: OC1=CC=C(C=CC=C2)C2=C1/C=N/NC(C3=CC=NC=C3)=O
• InChI: 1S/C17H13N3O2/c21-16-6-5-12-3-1-2-4-14(12)15(16)11-19-20-17(22)13-7-9-18-10-8-13/h1-11,21H,(H,20,22)/b19-11+
• InChI key: WQSHHAVECQJKLX-YBFXNURJSA-N

Descripción

Biochem/physiol Actions

AS8351 is an iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B), a histone H3K4 demethylase involved in regulation of cell proliferation and stem cell self-renewal and differentiation. AS8351 is thought to inhibit KDM5B by competing with a-ketoglutarate for chelating iron that KDM5B requires as a co-factor.

AS8351 is an iron chelator that has been found to inhibit of histone demethylase KDM5B (JARID1B).

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H315,H319,H335
• Indicaciones de precaución: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos diana: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable