SML1607

Lesinurad

≥98% (HPLC)

• Sinónimos: 2-[[5-Bromo-4-(4-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic acid, RDEA 594
• Fórmula empírica (notación de Hill): C₁₇H₁₄BrN₃O₂S
• Número CAS: 878672-00-5
• Peso molecular: 404.28
• NACRES: NA.77
• PubChem Substance ID: 329825493
• UNSPSC Code: 12352200
• MDL number: MFCD22572730
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 25 mg/mL, clear
• storage temp.: −20°C
• SMILES string: BrC1=NN=C(SCC(O)=O)N1C2=C3C(C=CC=C3)=C(C4CC4)C=C2
• InChI: 1S/C17H14BrN3O2S/c18-16-19-20-17(24-9-15(22)23)21(16)14-8-7-11(10-5-6-10)12-3-1-2-4-13(12)14/h1-4,7-8,10H,5-6,9H2,(H,22,23)
• InChI key: FGQFOYHRJSUHMR-UHFFFAOYSA-N
• Gene Information: human ... SLC22A12(116085)

Descripción

Biochem/physiol Actions

Lesinurad is a selective inhibitor of Urate transporter 1 (URAT1), a urate-anion exchanger which is responsible for the majority of uric acid reabsorption from the renal tubular lumen. Lesinurad thus reduces serum uric acid levels. Lesinurad has been approved for use in combination with a xanthine oxidase inhibitor to treat hyperuricemia associated with gout.

Lesinurad is a selective inhibitor of Urate transporter 1 (URAT1).

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable