SML1552

Tipiracil hydrochloride

≥98% (HPLC), thymidine phosphorylase inhibitor, powder

• Sinónimos: 5-Chloro-6-[(2-imino-1-pyrrolidinyl)methyl]-2,4(1H,3H)-pyrimidinedione hydrochloride, TPI hydrochloride
• Fórmula empírica (notación de Hill): C₉H₁₁ClN₄O₂ · HCl
• Número CAS: 183204-72-0
• Peso molecular: 279.12
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825960
• NACRES: NA.77
• MDL number: MFCD01571384
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Propiedades

• Nombre del producto: Tipiracil hydrochloride, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: 5 mg/mL, clear (warmed)
• storage temp.: 2-8°C
• SMILES string: [H]Cl.ClC1=C(CN2C(CCC2)=N)NC(NC1=O)=O
• InChI: 1S/C9H11ClN4O2.ClH/c10-7-5(12-9(16)13-8(7)15)4-14-3-1-2-6(14)11;/h11H,1-4H2,(H2,12,13,15,16);1H
• InChI key: KGHYQYACJRXCAT-UHFFFAOYSA-N
• Gene Information: human ... TYMP(1890)

Descripción

Biochem/physiol Actions

Tipiracil is an inhibitor of thymidine phosphorylase.

Tipiracil is an inhibitor of thymidine phosphorylase. Tipiracil is used in combination with trifluridine as TAS-102 for the treatment of refractory metastatic colorectal cancer. Tipiracil increases the bioavailability of trifluridine by blocking the enzyme that would otherwise protect the tumors by metabolizing trifluridine.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable