SML1476

Thiocolchicoside

≥98% (HPLC)

• Sinónimos: (S)-N-[3-(β-D-glucopyranosyloxy)-1,2-dimethoxy-10(methylthio)-9-oxo-5,6,7,9-tetrahydrobenzo [a] heptalen-7-yl] acetamide, 2-Demethoxy-2-glucosidoxythiocolchicine
• Fórmula empírica (notación de Hill): C₂₇H₃₃NO₁₀S
• Número de CAS: 602-41-5
• Peso molecular: 563.62
• Número CE: 210-017-7
• Número MDL: MFCD07995056
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825907
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• actividad óptica: [α]/D -510 to -610°, c = 0.5 in H₂O
• color: light yellow to dark yellow
• solubilidad: H₂O: 10 mg/mL, clear
• temp. de almacenamiento: −20°C
• cadena SMILES: O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC(CC[C@H](NC(C)=O)C(C3=CC=C4SC)=CC4=O)=C3C(OC)=C2OC)[C@@H]1O
• InChI: 1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)/t16-,19+,22+,23-,24+,27+/m0/s1
• Clave InChI: LEQAKWQJCITZNK-AXHKHJLKSA-N

Descripción

Acciones bioquímicas o fisiológicas

Thiocolchicoside acts as a muscle relaxant.[1] In experimental animals, thiocolchicoside results in malfunctions (teratogenic) and impairs chromosomes. It is advised to be used as an analgesic for patients with muscle pain, starting with paracetamol.[1] Thiocolchicoside can be used in irrigation solution at the time of endoscopic treatment of ureteral calculus to reduce the movement of stones.[2]

Thiocolchicoside is a potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist with muscle relaxant, anti-inflammatory, and analgesic activity.

Thiocolchicoside is a potent competitive γ-aminobutyric acid type A (GABAA) receptor antagonist and glycine receptor agonist with muscle relaxant, anti-inflammatory, and analgesic activity. Thiocolchicoside has also been found to suppress nuclear factor kappa B ligand (RANKL) activation of NF-KB resulting in suppression of osteoclastogenesis.

Información de seguridad

• Pictogramas: GHS06,GHS08
• Palabra de señalización: Danger
• Frases de peligro: H301,H341,H361fd,H372
• Consejos de prudencia: P201 - P301 + P310 + P330
• Clasificaciones de peligro: Acute Tox. 3 Oral - Muta. 2 - Repr. 2 - STOT RE 1
• Órganos de actuación: Gastro-intestinal system
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable