SML1386

Calindol hydrochloride

≥98% (HPLC)

• Sinónimos: (R)-2-[[[1-(1-Naphthyl)ethyl]amino]methyl]-1H-indole hydrochloride, N-[(1R)-1-(1-naphthalenyl)ethyl]-1H-Indole-2-methanamine hydrochloride
• Fórmula empírica (notación de Hill): C₂₁H₂₀N₂ · HCl
• Número CAS: 729610-18-8
• Peso molecular: 336.86
• NACRES: NA.77
• PubChem Substance ID: 329825834
• UNSPSC Code: 12352200
• MDL number: MFCD18382212
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: −20°C
• SMILES string: [H]Cl.C[C@@H](NCC1=CC2=C(N1)C=CC=C2)C3=CC=CC4=C3C=CC=C4
• InChI: 1S/C21H20N2.ClH/c1-15(19-11-6-9-16-7-2-4-10-20(16)19)22-14-18-13-17-8-3-5-12-21(17)23-18;/h2-13,15,22-23H,14H2,1H3;1H/t15-;/m1./s1
• InChI key: KFILKQPBQZIRST-XFULWGLBSA-N

Descripción

Biochem/physiol Actions

Calcimimetic; Ca Sensing Receptor (CaSR) Agonist

Calindol is a calcimimetic Ca Sensing Receptor (CaSR) agonist. It is a positive allosteric modulator (PAM) with an EC50 value of 1 μM and a maximum stimulation of 130% of the 10mM Ca2+ activation in triggering PI hydrolysis.

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H302
• Indicaciones de precaución: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable