SML1376
BTC
≥95% (HPLC)
Sinónimos:
2-(4-Hydroxyphenyl)-1-benzothiophene-6-ol, 2-(4-Hydroxyphenyl)benzo[b]thiophene-6-ol
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About This Item
Fórmula empírica (notación de Hill):
C14H10O2S
Número de CAS:
Peso molecular:
242.29
Código UNSPSC:
51111800
NACRES:
NA.77
Productos recomendados
Ensayo
≥95% (HPLC)
Formulario
powder
condiciones de almacenamiento
protect from light
color
white to light brown
solubilidad
DMSO: 20 mg/mL, clear
temp. de almacenamiento
−20°C
InChI
1S/C14H10O2S/c15-11-4-1-9(2-5-11)13-7-10-3-6-12(16)8-14(10)17-13/h1-8,15-16H
Clave InChI
MDGWZLQPNOETLH-UHFFFAOYSA-N
Acciones bioquímicas o fisiológicas
BTC is a selective estrogen receptor (ER) modulator (SERM) that acts as a selective estrogen mimic (SEM).
BTC is a selective estrogen receptor (ER) modulator (SERM) that acts as a selective estrogen mimic (SEM). BTC has been found to be both estrogenic and antiproliferative in ER-positive endocrine-resistant breast cancer cell lines that overexpress protein kinase C alpha (PKCα), which is often associated with tamoxifen resistance. BTC caused regression of endocrine-resistant breast cancer xenografts, and did not support the growth of hormone-dependent xenografts in vivo or cause an increase in uterine weight. As in the case with raloxifene and estradiol, BTC tumor regression was accompanied by the exit of ERα from the nucleus, suggesting extranuclear ERα may be involved in the mehanism of action.
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Acute Tox. 4 Oral
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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