SML1324

XEN445

≥98% (HPLC)

• Sinónimos: (S)-2-(3-(Pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid
• Fórmula empírica (notación de Hill): C₁₈H₁₇F₃N₂O₃
• Número CAS: 1515856-92-4
• Peso molecular: 366.33
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: FC(F)(F)c1cc(c(cc1)N2C[C@H](CC2)OCc3ncccc3)C(=O)O
• InChI: 1S/C18H17F3N2O3/c19-18(20,21)12-4-5-16(15(9-12)17(24)25)23-8-6-14(10-23)26-11-13-3-1-2-7-22-13/h1-5,7,9,14H,6,8,10-11H2,(H,24,25)/t14-/m0/s1
• InChI key: NBGRERFNOKZQLO-AWEZNQCLSA-N

Descripción

Biochem/physiol Actions

XEN445 is a potent and selective inhibitor of endothelial lipase with an IC₅₀ of 237 nM and high selectivity over hepatic and lipoprotein lipases. In experiments with wild-type mice, XEN445 raised plasma HDL-cholesterol levels by 16% after 3 days and by 30% after 9 days dosing.

XEN445 is a potent and selective inhibitor of endothelial lipase.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable