SML1060

Celecoxib-NBD

≥98% (HPLC)

• Sinónimos: N-(2-((7-Nitrobenzo[c]-[1,2,5]oxadiazol-4-yl)amino)ethyl)-4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide
• Fórmula empírica (notación de Hill): C₂₅H₂₀F₃N₇O₅S
• Peso molecular: 587.53
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: protect from light

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: yellow to orange
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: 2-8°C

Descripción

Biochem/physiol Actions

Celecoxib-NBD is a flourescent COX2-specific inhibitor.

Celecoxib-NBD is a flourescent COX2-specific inhibitor. The molecule binds to, and inhibits COX2 with an IC₅₀ of 0.19 μM, and a selectivity index of 443 for COX2 vs. COX1. Celecoxib-NBD fluorescently labels COX2-expressing HCA-7 colon cells, but not COX2-negative HCT116 cells.

Información de seguridad

• Pictogramas: GHS06
• Palabra de advertencia: Danger
• Códigos de peligro: H301,H413
• Indicaciones de precaución: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 4
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable