SML0826

FH1

≥98% (HPLC)

• Sinónimos: BRD-K4477, N,N′-(Methylenedi-4,1-phenylene)bis-acetamide, N,N′-(Methylenedi-4,1-phenylene)diacetamide, NSC 12407
• Fórmula empírica (notación de Hill): C₁₇H₁₈N₂O₂
• Número de CAS: 2719-05-3
• Peso molecular: 282.34
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Análisis: ≥98% (HPLC)
• formulario: powder
• color: white to beige
• solubilidad: DMSO: 10 mg/mL, clear (warmed)
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C17H18N2O2/c1-12(20)18-16-7-3-14(4-8-16)11-15-5-9-17(10-6-15)19-13(2)21/h3-10H,11H2,1-2H3,(H,18,20)(H,19,21)
• Clave InChI: OEXMNSOPAKOPEF-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

FH1 (BRD-K4477) was found to enhance hepatocyte functions and promote the differentiation of induced pluripotent stem cell–derived hepatocytes toward a more mature phenotype than what had previouslybeen obtainable. Human induced pluripotent stem (iPS) cells that are differentiated toward hepatocyte-like (iHep) cells typically show an immature hepatic phenotype and have limited use as a renewable source of functional human hepatocytes. Cultures treated with both FH1 (BRD-K4477) and another compound that induces proliferation, FPH1 (BRD-6125), contained larger colonies of iHep cells, which showed more pronounced hepatocyte morphologies with a more mature phenotype than previously obtainable.

Información de seguridad

• Pictogramas: GHS09
• Palabra de señalización: Warning
• Frases de peligro: H400
• Consejos de prudencia: P273 - P391 - P501
• Clasificaciones de peligro: Aquatic Acute 1
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable