SML0681

Febrifugine dihydrochloride

≥95% (HPLC)

• Sinónimos: 3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone dihydrochloride
• Fórmula empírica (notación de Hill): C₁₆H₁₉N₃O₃ · 2HCl
• Número CAS: 32434-42-7
• Peso molecular: 374.26
• UNSPSC Code: 51111800
• PubChem Substance ID: 329825583
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: powder
• Storage condition: desiccated

Propiedades

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• optical activity: [α]/D 10 to 15°, c = 1 in H₂O
• storage condition: desiccated
• color: off-white to gray-brown
• solubility: H₂O: 15 mg/mL, clear
• storage temp.: −20°C
• SMILES string: O=C1C2=CC=CC=C2N=CN1CC(C[C@@H]3[C@@H](O)CCCC3)=O.C
• InChI: 1S/C17H20N2O3.CH4/c20-13(9-12-5-1-4-8-16(12)21)10-19-11-18-15-7-3-2-6-14(15)17(19)22;/h2-3,6-7,11-12,16,21H,1,4-5,8-10H2;1H4/t12-,16+;/m1./s1
• InChI key: SNTOTCUGCWLHEZ-KKJWGQAZSA-N

Descripción

Biochem/physiol Actions

Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan. Recent studies indicate that its mechanism of action is as an inhibitor of prolyl-transfer RNA synthetase (ProRS).

Febrifugine is an antimalarial, the active component of the Chinese herb Chang Shan; inhibitor of prolyl-transfer RNA synthetase (ProRS).

Febrifugine dihydrochloride exhibits strong antimalarial activity against Plasmodium falciparum, the most insidious malaria causative agent. The adverse effects of febrifugine include diarrhoea, vomiting and liver toxicity.

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H302
• Indicaciones de precaución: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable