SML0414

NCX 4040

≥98% (HPLC)

• Sinónimos: 2-(Acetyloxy)benzoic acid 4-(nitroxymethyl)phenyl ester, NO-aspirin
• Fórmula empírica (notación de Hill): C₁₆H₁₃NO₇
• Número CAS: 287118-97-2
• Peso molecular: 331.28
• NACRES: NA.77
• PubChem Substance ID: 329825409
• UNSPSC Code: 12352200
• MDL number: MFCD08062164
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: protect from light

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: white to beige
• solubility: DMSO: 15 mg/mL (clear solution)
• storage temp.: −20°C
• SMILES string: CC(=O)Oc1ccccc1C(=O)Oc2ccc(CO[N+]([O-])=O)cc2
• InChI: 1S/C16H13NO7/c1-11(18)23-15-5-3-2-4-14(15)16(19)24-13-8-6-12(7-9-13)10-22-17(20)21/h2-9H,10H2,1H3
• InChI key: CTHNKWFUDCMLIQ-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

NCX 4040 is a nitric oxide-donating form of aspirin.

NCX 4040 is a nitric oxide-donating form of aspirin. NCX 4040 inhibits cyclooxygenase activity and releases NO, which can down-regulate COX2 expression and reduce the levels of superoxide accumulation. In the human monocytic cell line THP1, the compound inhibits PGE2 production and cytokine expression, and appears to stabilize IkB by inhibiting proteasome function. NCX 4040 has been shown to induce apoptosis in several tumor cell lines.

Features and Benefits

This compound is featured on the Nitric Oxide Synthases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS05,GHS07,GHS09
• Palabra de advertencia: Danger
• Códigos de peligro: H317,H318,H400
• Indicaciones de precaución: P273 - P280 - P302 + P352 - P305 + P351 + P338 + P310
• Hazard Classifications: Aquatic Acute 1 - Eye Dam. 1 - Skin Sens. 1
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable