SML0385

ML218

≥98% (HPLC)

• Sinónimos: 3,5-Dichloro-N-[[(1α,5α,6-exo,6α)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]benzamide, CID 45115620, VU0413807, VU0424199-1
• Fórmula empírica (notación de Hill): C₁₉H₂₆Cl₂N₂O
• Número CAS: 1346233-68-8
• Peso molecular: 369.33
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825385
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 10 mg/mL (clear solution)
• storage temp.: 2-8°C
• SMILES string: CC(C)(C)CCN1C[C@H]2C(CNC(=O)c3cc(Cl)cc(Cl)c3)[C@H]2C1
• InChI: 1S/C19H26Cl2N2O/c1-19(2,3)4-5-23-10-16-15(17(16)11-23)9-22-18(24)12-6-13(20)8-14(21)7-12/h6-8,15-17H,4-5,9-11H2,1-3H3,(H,22,24)/t15-,16-,17+
• InChI key: GSJIGYLGKSBYBC-OSYLJGHBSA-N

Descripción

Application

ML218 has been used as a:

• T-type channel blocker to test its effect on the nociceptive behavior associated with homocysteinemia rats
• T-type voltage-sensitive calcium channel (VSCC) inhibitor in osteoblasts
• T-type calcium channel blocker to test its effect on the viability of neural progenitor cells

Biochem/physiol Actions

ML218 (CID 45115620) is a potent and selective T-Type (Cav3.1, Cav3.2, Cav3.3) calcium channel inhibitor (Cav3.2, IC50 = 150 nM in Ca2+ flux; Cav3.2 IC50 = 310 nM and Cav3.3 IC50 = 270 nM with good Drug metabolism/Pharmacokinetics. In a panel of 68 GPCRs, ion channels and transporters, ML218 was found to bind significantly only two other targets (sodium channel site 2 and sigma 1) and had no significant inhibition of L- or N-type calcium channels, KATP or hERG potassium channels. It showed robust inhibition of calcium current in STN neurons and was orally active in a rodent model of Parkinson′s Disease.

ML218 is a potent, selective T-Type calcium channel inhibitor.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable