SML0370

Kartogenin

≥98% (HPLC), runt-related transcription factor 1 (RUNX1) regulator, powder

• Sinónimos: 2-[(Biphenyl-4-yl)carbamoyl]benzoic acid, 4′-Phenyl-phthalanilic acid (8CI), KGN
• Fórmula empírica (notación de Hill): C₂₀H₁₅NO₃
• Número CAS: 4727-31-5
• Peso molecular: 317.34
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825371
• NACRES: NA.77
• MDL number: MFCD00560510
• Assay: ≥98% (HPLC)
• Form: powder

Propiedades

• Nombre del producto: Kartogenin, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• solubility: DMSO: >15 mg/mL
• storage temp.: room temp
• SMILES string: O=C(NC1=CC=C(C2=CC=CC=C2)C=C1)C(C=CC=C3)=C3C(O)=O
• InChI: 1S/C20H15NO3/c22-19(17-8-4-5-9-18(17)20(23)24)21-16-12-10-15(11-13-16)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)
• InChI key: SLUINPGXGFUMLL-UHFFFAOYSA-N

Descripción

Biochem/physiol Actions

Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes.

Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ.

Kartogenin is a small heterocyclic compound. It is involved in regulating runt-related transcription factor 1 (RUNX1), which plays an important role in chondrocyte proliferation and survival.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3