SML0346

Alosetron hydrochloride

≥98% (HPLC)

• Sinónimos: 2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one hydrochloride
• Fórmula empírica (notación de Hill): C₁₇H₁₈N₄O·HCl
• Número CAS: 122852-69-1
• Peso molecular: 330.81
• NACRES: NA.77
• PubChem Substance ID: 329825350
• UNSPSC Code: 12352200
• MDL number: MFCD09028027
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: H₂O: ≥5 mg/mL at warmed
• storage temp.: 2-8°C
• SMILES string: CN1C2=C(C=CC=C2)C3=C1CCN(CC4=C(C)N=CN4)C3=O.Cl
• InChI: 1S/C17H18N4O.ClH/c1-11-13(19-10-18-11)9-21-8-7-15-16(17(21)22)12-5-3-4-6-14(12)20(15)2;/h3-6,10H,7-9H2,1-2H3,(H,18,19);1H
• InChI key: FNYQZOVOVDSGJH-UHFFFAOYSA-N
• Gene Information: human ... HTR3A(3359)

Descripción

Biochem/physiol Actions

Alosetron is a potent and highly selective antagonist of serotonin 5-HT3 receptors, nonselective cation channels found predominantly in the enteric nervous system of the gastrointestinal tract. These receptors are involved in the regulation of visceral pain, colonic transit and GI secretions that can contribute to the pathophysiology of irritable bowel syndrome (IBS). Alosetron is used clinically for treatment of women with severe diarrhea-predominant IBS.

Alosetron is a potent and highly selective antagonist.

Información de seguridad

• Pictogramas: GHS06
• Palabra de advertencia: Danger
• Códigos de peligro: H301,H319,H412
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2
• Clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• Indicaciones de precaución: P264 - P273 - P280 - P301 + P310 - P305 + P351 + P338 - P337 + P313