SML0300

Aib-1 trifluoroacetate salt

≥98% (HPLC)

• Sinónimos: Tyr-Aib-Trp-Phe trifluoroacetate salt
• Fórmula empírica (notación de Hill): C₃₃H₃₇N₅O₆ · xC₂HF₃O₂
• Número de CAS: 1334763-90-4
• Peso molecular: 599.68 (free base basis)
• Código UNSPSC: 12352202
• ID de la sustancia en PubChem: 329825306
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: lyophilized solid
• color: white to beige
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• cadena SMILES: OC(=O)C(F)(F)F.CC(C)(NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc2cc3ccccc3[nH]2)C(=O)N[C@@H](Cc4ccccc4)C(O)=O
• InChI: 1S/C33H37N5O6.C2HF3O2/c1-33(2,38-29(40)25(34)16-21-12-14-24(39)15-13-21)32(44)37-27(19-23-18-22-10-6-7-11-26(22)35-23)30(41)36-28(31(42)43)17-20-8-4-3-5-9-20;3-2(4,5)1(6)7/h3-15,18,25,27-28,35,39H,16-17,19,34H2,1-2H3,(H,36,41)(H,37,44)(H,38,40)(H,42,43);(H,6,7)/t25-,27-,28-;/m0./s1
• Clave InChI: NELSAMPJZPTPEG-MDQBHWJISA-N

Descripción

Acciones bioquímicas o fisiológicas

Aib-1 is an inhibitor of β-Amyloid oligomerization.

Aib-1 is an inhibitor of β-Amyloid oligomerization. Aib-1 is an endomorphin analog more stable to enzymatic degradation and incorporating the β-breaker 2 aminoisobutyric acid. It interacted with Aβ and markedly inhibited the formation of toxic oligomer and fibril growth using in vitro assays, prevented Aβ toxicity in neuronal PC12 cells, and increased longevity in a fly model of Alzheimer′s disease. Aib-1 activity is thought to be due to multi-mode interactions including aromatic, hydrophobic, and polar contacts with Aβ.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable