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SML0258

Sigma-Aldrich

CPPG

≥98% (HPLC)

Sinónimos:

(R,S)-α-Cyclopropyl-4-phosphonophenylglycine

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About This Item

Fórmula empírica (notación de Hill):
C11H14NO5P
Número de CAS:
183364-82-1
Peso molecular:
271.21
Número MDL:
MFCD00673967
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329825266
NACRES:
NA.77

Análisis

≥98% (HPLC)

formulario

powder

condiciones de almacenamiento

desiccated

color

white to beige

solubilidad

H2O: >5 mg/mL

temp. de almacenamiento

room temp

cadena SMILES

NC(C1CC1)(C(O)=O)c2ccc(cc2)P(O)(O)=O

InChI

1S/C11H14NO5P/c12-11(10(13)14,7-1-2-7)8-3-5-9(6-4-8)18(15,16)17/h3-7H,1-2,12H2,(H,13,14)(H2,15,16,17)

Clave InChI

IGODGTDUQSMDQU-UHFFFAOYSA-N

Acciones bioquímicas o fisiológicas

(R,S)-α-Cyclopropyl-4-phosphonophenylglycine (CPPG) can be used in combination with scopolamine to treat the depressive disorder.
CPPG is a potent group II/III metabotropic glutamate receptor antagonist, with approximately 20-fold selectivity for mGlu group III over group II (IC50 values of 2.2 and 46.2 nM respectively).

Características y beneficios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

13 - Non Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Kouji Fukuyama et al.
Biomolecules, 9(6) (2019-06-20)
Pharmacological mechanisms of gold-standard antipsychotics against treatment-refractory schizophrenia, such as clozapine (CLZ), remain unclear. We aimed to explore the mechanisms of CLZ by investigating the effects of MK801 and CLZ on tripartite synaptic transmission in the thalamocortical glutamatergic pathway using
Emmanuel Dornier et al.
Nature communications, 8(1), 2255-2255 (2017-12-23)
The role of glutaminolysis in providing metabolites to support tumour growth is well-established, but the involvement of glutamine metabolism in invasive processes is yet to be elucidated. Here we show that normal mammary epithelial cells consume glutamine, but do not
Mohaddeseh Ebrahimi-Ghiri et al.
Physiology & behavior, 224, 113034-113034 (2020-07-01)
Clinical trials have revealed that the muscarinic receptor antagonist scopolamine produces a fast and potent antidepressant response. However, the anticholinergic adverse effects and the risk of psychosis at higher doses limit the widespread clinical use of scopolamine. Combination therapy of
Chantalle Briggs et al.
Neuropharmacology, 154, 50-60 (2018-12-27)
Sleep/wake states are controlled by sleep- and wake-promoting systems, and transitions between states are thought to be regulated by their reciprocal inhibition and homeostatic sleep need. Orexin neurons are known to promote wake maintenance and stabilize the sleep/wake switch. Thus
Helena Domin et al.
Neuropharmacology, 102, 276-294 (2015-12-10)
In the present study, we investigated the effect of ACPT-I [(1S, 3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid], a blood-brain-barrier permeable agonist of group III mGlu receptor, against oxygen-glucose deprivation (OGD)-evoked neuronal cell death in primary neuronal cell cultures and in the model of transient
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