SML0103

AMTB hydrate

≥98% (HPLC)

• Sinónimos: N-(3-aminopropyl)-2-[(3-methylphenyl)methoxy]-N-(2-thienylmethyl)-benzamide hydrochloride (1:1) hyclate
• Fórmula empírica (notación de Hill): C₂₃H₂₆N₂O₂S·HCl · xH₂O
• Número CAS: 926023-82-7
• Peso molecular: 430.99 (anhydrous basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825160
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Propiedades

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to tan
• solubility: DMSO: ≥10 mg/mL
• storage temp.: 2-8°C
• SMILES string: O=C(C1=C(OCC2=C(C)C=CC=C2)C=CC=C1)N(CCCN)CC3=CC=CS3.Cl.O
• InChI: 1S/C23H26N2O2S.ClH.H2O/c1-18-8-2-3-9-19(18)17-27-22-12-5-4-11-21(22)23(26)25(14-7-13-24)16-20-10-6-15-28-20;;/h2-6,8-12,15H,7,13-14,16-17,24H2,1H3;1H;1H2
• InChI key: RTYVTAQFASBIDN-UHFFFAOYSA-N

Descripción

Application

AMTB hydrate has been used as an inhibitor of transient receptor potential cation channel, subfamily melastatin, member 8 (TRPM8) in breast cancer cells and murine T cells.

Biochem/physiol Actions

AMTB is a TRPM8 ion channel blocker

AMTB is a TRPM8-selective antagonist with no cross reactivity to TRPV1 or 4. The pIC50 of icilin activation of TRPM8 is 6.23 i.v. administration of AMTB reduced the frequency of rhythmic contractions in volume-loaded bladder and inhibited blood pressure and visceromotor reflex responses to bladder distention.

AMTB is a 2-benzyloxy-benzoic acid amide derivative, which also inhibits voltage-gated sodium channels (Nav) and their isoforms.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable